Discovery and Hit to Lead Optimization of Macrocyclic Peptides as Novel Tropomyosin Receptor Kinase A Antagonists
T Yamada, K Mihara, T Ueda, D Yamauchi… - Journal of Medicinal …, 2024 - ACS Publications
Tropomyosin receptor kinases (Trks) are receptor tyrosine kinases activated by neurotrophic
factors, called neurotrophins. Among them, TrkA interacts with the nerve growth factor (NGF) …
factors, called neurotrophins. Among them, TrkA interacts with the nerve growth factor (NGF) …
HighFold: accurately predicting structures of cyclic peptides and complexes with head-to-tail and disulfide bridge constraints
C Zhang, C Zhang, T Shang, N Zhu… - Briefings in …, 2024 - academic.oup.com
In recent years, cyclic peptides have emerged as a promising therapeutic modality due to
their diverse biological activities. Understanding the structures of these cyclic peptides and …
their diverse biological activities. Understanding the structures of these cyclic peptides and …