Biological roles of adenine methylation in RNA
K Boulias, EL Greer - Nature Reviews Genetics, 2023 - nature.com
Abstract N 6-Methyladenosine (m6A) is one of the most abundant modifications of the
epitranscriptome and is found in cellular RNAs across all kingdoms of life. Advances in …
epitranscriptome and is found in cellular RNAs across all kingdoms of life. Advances in …
An epigenetic role of mitochondria in cancer
Mitochondria are not only the main energy supplier but are also the cell metabolic center
regulating multiple key metaborates that play pivotal roles in epigenetics regulation. These …
regulating multiple key metaborates that play pivotal roles in epigenetics regulation. These …
The life and times of a tRNA
EM Phizicky, AK Hopper - RNA, 2023 - rnajournal.cshlp.org
The study of eukaryotic tRNA processing has given rise to an explosion of new information
and insights in the last several years. We now have unprecedented knowledge of each step …
and insights in the last several years. We now have unprecedented knowledge of each step …
Roles and regulation of tRNA-derived small RNAs in animals
S Muthukumar, CT Li, RJ Liu, C Bellodi - Nature Reviews Molecular Cell …, 2024 - nature.com
A growing class of small RNAs, known as tRNA-derived RNAs (tdRs), tRNA-derived small
RNAs or tRNA-derived fragments, have long been considered mere intermediates of tRNA …
RNAs or tRNA-derived fragments, have long been considered mere intermediates of tRNA …
RNA nucleotide methylation: 2021 update
Among RNA modifications, transfer of methylgroups from the typical cofactor S‐adenosyl‐l‐
methionine by methyltransferases (MTases) to RNA is by far the most common reaction …
methionine by methyltransferases (MTases) to RNA is by far the most common reaction …
RNA methylation in mammalian development and cancer
P Song, S Tayier, Z Cai, G Jia - Cell Biology and Toxicology, 2021 - Springer
Similar to epigenetic DNA and histone modifications, epitranscriptomic modifications (RNA
modifications) have emerged as crucial regulators in temporal and spatial gene expression …
modifications) have emerged as crucial regulators in temporal and spatial gene expression …
Epitranscriptomics in metabolic disease
Y Matsumura, FY Wei, J Sakai - Nature Metabolism, 2023 - nature.com
While epigenetic modifications of DNA and histones play main roles in gene transcription
regulation, recently discovered post-transcriptional RNA modifications, known as …
regulation, recently discovered post-transcriptional RNA modifications, known as …
Queuosine‐tRNA promotes sex‐dependent learning and memory formation by maintaining codon‐biased translation elongation speed
C Cirzi, J Dyckow, C Legrand, J Schott, W Guo… - The EMBO …, 2023 - embopress.org
Queuosine (Q) is a modified nucleoside at the wobble position of specific tRNAs. In
mammals, queuosinylation is facilitated by queuine uptake from the gut microbiota and is …
mammals, queuosinylation is facilitated by queuine uptake from the gut microbiota and is …
Human transfer RNA modopathies: diseases caused by aberrations in transfer RNA modifications
T Chujo, K Tomizawa - The FEBS journal, 2021 - Wiley Online Library
tRNA molecules are post‐transcriptionally modified by tRNA modification enzymes.
Although composed of different chemistries, more than 40 types of human tRNA …
Although composed of different chemistries, more than 40 types of human tRNA …
RNA modification: mechanisms and therapeutic targets
L Qiu, Q Jing, Y Li, J Han - Molecular Biomedicine, 2023 - Springer
RNA modifications are dynamic and reversible chemical modifications on substrate RNA
that are regulated by specific modifying enzymes. They play important roles in the regulation …
that are regulated by specific modifying enzymes. They play important roles in the regulation …