Membrane lipid composition: effect on membrane and organelle structure, function and compartmentalization and therapeutic avenues

D Casares, PV Escribá, CA Rosselló - International journal of molecular …, 2019 - mdpi.com
Biological membranes are key elements for the maintenance of cell architecture and
physiology. Beyond a pure barrier separating the inner space of the cell from the outer, the …

Role of lipids in the interaction of antimicrobial peptides with membranes

V Teixeira, MJ Feio, M Bastos - Progress in lipid research, 2012 - Elsevier
Antimicrobial peptides (AMPs) take part in the immune system by mounting a first line of
defense against pathogens. Recurrent structural and functional aspects are observed …

[HTML][HTML] The effect of natural and synthetic fatty acids on membrane structure, microdomain organization, cellular functions and human health

M Ibarguren, DJ López, PV Escribá - Biochimica et Biophysica Acta (BBA) …, 2014 - Elsevier
This review deals with the effects of synthetic and natural fatty acids on the biophysical
properties of membranes, and on their implication on cell function. Natural fatty acids are …

Oleic acid content is responsible for the reduction in blood pressure induced by olive oil

S Teres, G Barceló-Coblijn, M Benet… - Proceedings of the …, 2008 - National Acad Sciences
Numerous studies have shown that high olive oil intake reduces blood pressure (BP). These
positive effects of olive oil have frequently been ascribed to its minor components, such as α …

Membrane lipid therapy: Modulation of the cell membrane composition and structure as a molecular base for drug discovery and new disease treatment

PV Escribá, X Busquets, J Inokuchi, G Balogh… - Progress in lipid …, 2015 - Elsevier
Nowadays we understand cell membranes not as a simple double lipid layer but as a
collection of complex and dynamic protein–lipid structures and microdomains that serve as …

Membranes: a meeting point for lipids, proteins and therapies

PV Escribá, JM González‐Ros, FM Goñi… - Journal of cellular …, 2008 - Wiley Online Library
• Introduction• Membrane lipid composition• Membrane lipid structure• Membrane lipid
organization‐Why so many different lipids?‐Lipid mixing and demixing‐Lateral pressure …

Antitumor effect of oleic acid; mechanisms of action. A review

C Carrillo Pérez, MM Cavia Camarero… - … Hospitalaria, 2012, v …, 2012 - riubu.ubu.es
Introduction: The beneficial effects of oleic acid in cancer processes can no longer be
doubted, but little is known about the mechanisms of action behind this phenomenon. Aim …

Membrane-lipid therapy: a new approach in molecular medicine

PV Escribá - Trends in molecular medicine, 2006 - cell.com
Although most drugs bind to proteins and regulate their activity, some drugs act through a
new therapeutic approach called membrane-lipid therapy and bind to lipids, thus modulating …

[HTML][HTML] Key role of lipids in heat stress management

G Balogh, M Péter, A Glatz, I Gombos, Z Török… - FEBS letters, 2013 - Elsevier
Heat stress is a common and, therefore, an important environmental impact on cells and
organisms. While much attention has been paid to severe heat stress, moderate temperature …

Fatty acid 2-Hydroxylation in mammalian sphingolipid biology

H Hama - Biochimica et Biophysica Acta (BBA)-Molecular and …, 2010 - Elsevier
2-Hydroxy fatty acids (hFA) are important components of a subset of mammalian
sphingolipids. The presence of hFA in sphingolipids is best described in the nervous system …