Adenosine triphosphate (ATP) accumulates at sites of tissue injury and inflammation. Effects
of extracellular ATP are mediated by plasma membrane receptors named P2 receptors …

Reciprocal signalling between immunocompetent cells in the central nervous system (CNS)
has emerged as a key phenomenon underpinning pathological and chronic pain …

Although extracellular ATP is abundant at sites of inflammation, its role in activating
inflammasome signalling in neutrophils is not well characterized. In the current study, we …

The P2X7 receptor is a cation channel activated by high concentrations of adenosine
triphosphate (ATP). Upon long-term activation, it complexes with membrane proteins forming …

The ATP-sensitive homomeric P2X7 receptor (P2X7R) has received particular attention as a
potential drug target because of its widespread involvement in inflammatory diseases as a …

The P2X7 receptor is a trimeric ATP-gated cation channel found predominantly, but not
exclusively, on immune cells. P2X7 activation results in a number of downstream events …

Mammalian ATP-gated nonselective cation channels (P2XRs) can be composed of seven
possible subunits, denoted P2X1 to P2X7. Each subunit contains a large ectodomain, two …

The P2X7 receptor is a trimeric ion channel gated by extracellular adenosine 5′-
triphosphate. The receptor is present on an increasing number of different cells types …

The P2X7 channel is involved in the pathogenesis of various CNS diseases. An increasing
number of studies suggest its presence in neurons where its putative functions remain …

ATP is a (co) transmitter and signaling molecule in the CNS. It acts at a multitude of ligand-
gated cationic channels termed P2X to induce rapid depolarization of the cell membrane …