The discovery of new compounds with antitumoral activity has become one of the most
important goals in medicinal chemistry. One interesting group of chemotherapeutic agents …

DNA topoisomerases are important cellular enzymes found in almost all types of living cells
(eukaryotic and prokaryotic). These enzymes are essential for various DNA metabolic …

Cell-based assays are more complex than cell-free test systems but still reflect a highly
artificial cellular environment. Incorporation of organotypic 3-dimensional (3-D) culture …

New promising unsymmetrical bisacridine derivatives (UAs), have been developed. Three
groups including 36 compounds were synthesized by the condensation of 4-nitro or 4 …

DNA remains one of the main targets in antitumour drug design. Due to their polycyclic
planar structure, acridines interact with DNA by intercalation between base pairs and …

In this paper, UV–vis spectroscopy and fluorescence were combined to study the binding of
Calf thymus DNA (ct-DNA) with the anthacycline antibiotic drug pirarubicin (THP). Ethidium …

PURPOSE: C-1311 is a member of the novel imidazoacridinone family of anticancer agents.
This phase 1 trial was designed to investigate the safety, tolerability and preliminary anti …

Imidazoacridinones (IA) are a class of antitumor agents which includes C-1311, an
interesting drug in clinical trials. This study investigated the mechanism of IA binding to DNA …

A method is presented for the electroanalytical characterization of interactions of dsDNA with
a drug, under conditions that both agents are dissolved in the phosphate buffer solution and …

The imidazoacridinone derivative, C-1311, is an antitumor agent that has been under phase
I of clinical trial. The work presented here aims to elucidate the molecular mechanism of the …