Advanced hepatocellular carcinoma (HCC) is a formidable public health problem with
limited curable treatment options. Axitinib, an oral tyrosine kinase inhibitor, is a potent and …

Who: This position statement is a collaborative effort by the American Academy of Clinical
Toxicology (AACT) and the American Association of Poison Control Centers (AAPCC) and …

Background: Phthalates are used as plasticizers in the manufacturing of flexible, plastic
medical products. Patients can be subjected to high phthalate exposure through contact with …

Introduction hERG block potency is widely used to calculate a drug's safety margin against
its torsadogenic potential. Previous studies are confounded by use of different patch clamp …

Loperamide has been a safe and effective treatment for diarrhea for many years. However,
many cases of cardiotoxicity with intentional abuse of loperamide ingestion have recently …

According to the ICH S7B guideline, drug candidates are screened for hERG block prior to
first-in-human testing to predict the likelihood of delayed repolarization associated with a …

Abuse of the common anti-diarrheal loperamide is associated with QT interval prolongation
as well as development of the potentially fatal arrhythmia torsades de pointes. The …

As a relatively new discipline, quantitative systems pharmacology has seen a significant
increase in the application and utility of drug development. One area that could greatly …

Introduction Loperamide, an antidiarrheal agent, is a µ‐opioid receptor agonist increasingly
abused to prevent opioid withdrawal or to produce euphoric effects. At supra‐therapeutic …

Background Cytochrome P450 3A4 (CYP3A4) appears to be genetically polymorphic, which
in turn contributes to interindividual variability in response to therapeutic drugs. Loperamide …