Therapeutic targeting of NF-κB in acute lung injury: a double-edged sword
Acute lung injury/acute respiratory distress syndrome (ALI/ARDS) is a devastating disease
that can be caused by a variety of conditions including pneumonia, sepsis, trauma, and most …
that can be caused by a variety of conditions including pneumonia, sepsis, trauma, and most …
[HTML][HTML] Mechanisms of endothelial regeneration and vascular repair and their application to regenerative medicine
CE Evans, ML Iruela-Arispe, YY Zhao - The American journal of pathology, 2021 - Elsevier
Endothelial barrier integrity is required for maintaining vascular homeostasis and fluid
balance between the circulation and surrounding tissues and for preventing the …
balance between the circulation and surrounding tissues and for preventing the …
Endothelial FoxM1 reactivates aging-impaired endothelial regeneration for vascular repair and resolution of inflammatory lung injury
X Huang, X Zhang, N Machireddy, CE Evans… - Science translational …, 2023 - science.org
Aging is a major risk factor of high incidence and increased mortality of acute respiratory
distress syndrome (ARDS). Here, we demonstrated that persistent lung injury and high …
distress syndrome (ARDS). Here, we demonstrated that persistent lung injury and high …
[HTML][HTML] mtDNA activates cGAS signaling and suppresses the YAP-mediated endothelial cell proliferation program to promote inflammatory injury
Cytosolic DNA acts as a universal danger-associated molecular pattern (DAMP) signal;
however, the mechanisms of self-DNA release into the cytosol and its role in inflammatory …
however, the mechanisms of self-DNA release into the cytosol and its role in inflammatory …
From anti-SARS-CoV-2 immune responses to COVID-19 via molecular mimicry
D Kanduc - Antibodies, 2020 - mdpi.com
Aim: To define the autoimmune potential of Severe Acute Respiratory Syndrome
Coronavirus 2 (SARS-CoV-2) infection. Methods: Experimentally validated epitopes …
Coronavirus 2 (SARS-CoV-2) infection. Methods: Experimentally validated epitopes …
Endothelial regeneration of large vessels is a biphasic process driven by local cells with distinct proliferative capacities
The cellular and mechanistic bases underlying endothelial regeneration of adult large
vessels have proven challenging to study. Using a reproducible in vivo aortic endothelial …
vessels have proven challenging to study. Using a reproducible in vivo aortic endothelial …
[HTML][HTML] Robust genome editing in adult vascular endothelium by nanoparticle delivery of CRISPR-Cas9 plasmid DNA
Vascular endothelium plays a crucial role in vascular homeostasis and tissue fluid balance.
To target endothelium for robust genome editing, we developed poly (ethylene glycol) …
To target endothelium for robust genome editing, we developed poly (ethylene glycol) …
miR-133: a suppressor of cardiac remodeling?
N Li, H Zhou, Q Tang - Frontiers in pharmacology, 2018 - frontiersin.org
Cardiac remodeling, which is characterized by mechanical and electrical remodeling, is a
significant pathophysiological process involved in almost all forms of heart diseases …
significant pathophysiological process involved in almost all forms of heart diseases …
Endothelial and smooth muscle cell interaction via FoxM1 signaling mediates vascular remodeling and pulmonary hypertension
Rationale: Angioproliferative vasculopathy is a hallmark of pulmonary arterial hypertension
(PAH). However, little is known about how endothelial cell (EC) and smooth muscle cell …
(PAH). However, little is known about how endothelial cell (EC) and smooth muscle cell …
Gradual hydrogel degradation for programable repairing full-thickness skin defect wound
Full-thickness skin defect wound infection seriously threatens the life and health of patients.
Highly efficient antibacterial activity and angiogenesis after injury are critical for the wound …
Highly efficient antibacterial activity and angiogenesis after injury are critical for the wound …