Emerging antiviral therapeutics for human adenovirus infection: Recent developments and novel strategies

MJ Dodge, KM MacNeil, TM Tessier, JB Weinberg… - Antiviral research, 2021 - Elsevier
Human adenoviruses (HAdV) are ubiquitous human pathogens that cause a significant
burden of respiratory, ocular, and gastrointestinal illnesses. Although HAdV infections are …

Multicenter evaluation of the BioFire FilmArray pneumonia/pneumonia plus panel for detection and quantification of agents of lower respiratory tract infection

CN Murphy, R Fowler, JM Balada-Llasat… - Journal of Clinical …, 2020 - Am Soc Microbiol
The ability to provide timely identification of the causative agents of lower respiratory tract
infections can promote better patient outcomes and support antimicrobial stewardship …

Cost-effective respiratory virus testing

BA Pinsky, RT Hayden - Journal of Clinical Microbiology, 2019 - Am Soc Microbiol
The timely and accurate diagnosis of respiratory virus infections has the potential to optimize
downstream (posttesting) use of limited health care resources, including antibiotics …

Epidemiology of respiratory pathogens in children with severe acute respiratory infection and impact of the multiplex PCR film array respiratory panel: a 2‐year study

A Lamrani Hanchi, M Guennouni… - International Journal …, 2021 - Wiley Online Library
Sever acute respiratory infections (SARIs) are a public health issue that are common in
children and are associated with an important morbidity and mortality rate worldwide …

Point-of-care and rapid tests for the etiological diagnosis of respiratory tract infections in children: a systematic review and meta-analysis

G Brigadoi, A Gastaldi, M Moi, E Barbieri, S Rossin… - Antibiotics, 2022 - mdpi.com
Fever is one of the most common causes of medical evaluation of children, and early
discrimination between viral and bacterial infection is essential to reduce inappropriate …

Antimicrobial stewardship program in pediatric medicine

V Probst, F Islamovic, A Mirza - Pediatric investigation, 2021 - mednexus.org
The rising threats from antimicrobial resistance due to inappropriate utilization of
antimicrobial agents in health care including the pediatric population has been a topic of …

The impact analysis of a multiplex PCR respiratory panel for hospitalized pediatric respiratory infections in Japan

T Kitano, H Nishikawa, R Suzuki, M Onaka… - Journal of Infection and …, 2020 - Elsevier
Background Rapid molecular diagnosis of infections has contributed to timely treatments
and antimicrobial stewardship. However, the benefit and cost-effectiveness vary in each …

Influenza antiviral treatment and length of stay

AP Campbell, JI Tokars, S Reynolds, S Garg… - …, 2021 - publications.aap.org
BACKGROUND Antiviral treatment is recommended for hospitalized patients with suspected
and confirmed influenza, but evidence is limited among children. We evaluated the effect of …

Opportunities revealed for antimicrobial stewardship and clinical practice with implementation of a rapid respiratory multiplex assay

ZF Weiss, CB Cunha, AB Chambers… - Journal of clinical …, 2019 - Am Soc Microbiol
Few studies assess the utility of rapid multiplex molecular respiratory panels in adult
patients. Previous multiplex PCR assays took hours to days from order time to result. We …

A pragmatic randomized controlled trial of rapid on-site influenza and respiratory syncytial virus PCR testing in paediatric and adult populations

HL Bibby, L de Koning, I Seiden-Long, N Zelyas… - BMC Infectious …, 2022 - Springer
Background Rapid/point-of-care respiratory virus nucleic acid tests (NAT) may improve
oseltamivir, antibiotic, diagnostic test, and hospital bed utilization. Previous randomized …