The disconnection hypothesis suggests that the core symptoms of schizophrenia (SZ) are
related to aberrant, or 'dys-', connectivity between distinct brain regions. A proliferation of …

After decades of research aimed at elucidating the pathophysiology and etiology of
schizophrenia, it has become increasingly apparent that it is an illness knowing few …

Early prenatal inflammatory conditions are thought to be a risk factor for different
neurodevelopmental disorders. Maternal interleukin-6 (IL-6) elevation during pregnancy …

Understanding the organization of the cerebral cortex remains a central focus of
neuroscience. Cortical maps have relied almost exclusively on the examination of …

Background Genome-wide association studies have identified several common risk loci for
schizophrenia (SCZ). In parallel, neuroimaging studies have shown consistent findings of …

The prefrontal cortex (PFC) elaborates and differentiates in primates, and there is a
corresponding elaboration in cortical dopamine (DA). DA cells that fire to both aversive and …

The symptoms of schizophrenia involve profound dysfunction of the prefrontal cortex (PFC).
PFC networks create our “mental sketch pad”, and PFC dysfunction contributes to symptoms …

The regulators of G-protein signaling (RGS) proteins were initially characterized as inhibitors
of signal transduction cascades initiated by G-protein-coupled receptors (GPCR) because of …

The small effect size of most individual risk factors for psychiatric disorders likely reflects
biological heterogeneity and diagnostic imprecision, which has encouraged genetic studies …

Context Studies have shown patterns of abnormal dorsolateral prefrontal cortex (DLPFC)
functional connectivity with other brain areas in schizophrenia and association of these …