Oxidative stress, inflammation, gut dysbiosis: what can polyphenols do in inflammatory bowel disease?

L Li, P Peng, N Ding, W Jia, C Huang, Y Tang - Antioxidants, 2023 - mdpi.com
Inflammatory bowel disease (IBD) is a long-term, progressive, and recurrent intestinal
inflammatory disorder. The pathogenic mechanisms of IBD are multifaceted and associated …

Foodomics-Based Approaches Shed Light on the Potential Protective Effects of Polyphenols in Inflammatory Bowel Disease

G Pratelli, B Tamburini, D Carlisi, A De Blasio… - International Journal of …, 2023 - mdpi.com
Inflammatory bowel disease (IBD) is a chronic and progressive inflammatory disorder
affecting the gastrointestinal tract (GT) caused by a wide range of genetic, microbial, and …

TGR5 deficiency in excitatory neurons ameliorates Alzheimer's pathology by regulating APP processing

C Li, L Wang, W Xie, E Chen, Y Chen, H Li, D Can… - Science …, 2024 - science.org
Bile acids (BAs) metabolism has a significant impact on the pathogenesis of Alzheimer's
disease (AD). We found that deoxycholic acid (DCA) increased in brains of AD mice at an …

Nrf2: a main responsive element of the toxicity effect caused by trichothecene (T-2) mycotoxin

Y Wang, Y Liu, T Huang, Y Chen, W Song, F Chen… - Toxics, 2023 - mdpi.com
T-2 toxin, the most toxic type A trichothecene mycotoxin, is produced by Fusarium, and is
widely found in contaminated feed and stored grains. T-2 toxin is physicochemically stable …

Pictolysin-III, a Hemorrhagic Type-III Metalloproteinase Isolated from Bothrops pictus (Serpentes: Viperidae) Venom, Reduces Mitochondrial Respiration and Induces …

DE Vivas-Ruiz, P Rosas, A Proleón, D Torrejón, F Lazo… - Pharmaceutics, 2023 - mdpi.com
From the venom of the Bothrops pictus snake, an endemic species from Peru, we recently
have described toxins that inhibited platelet aggregation and cancer cell migration. In this …

DAMP-ING IBD: Extinguish the fire and prevent smoldering

O Sandys, PCF Stokkers, AA Te Velde - Digestive Diseases and Sciences, 2024 - Springer
In inflammatory bowel diseases (IBD), the most promising therapies targeting cytokines or
immune cell trafficking demonstrate around 40% efficacy. As IBD is a multifactorial …

Mitochondrial quality control in human health and disease

BH Liu, CZ Xu, Y Liu, ZL Lu, TL Fu, GR Li… - Military Medical …, 2024 - Springer
Mitochondria, the most crucial energy-generating organelles in eukaryotic cells, play a
pivotal role in regulating energy metabolism. However, their significance extends beyond …

Maternal Intake of Laminarin Improves Infant Growth and Health by Fortifying Metabolite Profiles of Colostrum and Milk

P Zhang, X Yue, E Yan, L He, B Wan… - Journal of Agricultural …, 2024 - ACS Publications
Laminarin mainly consists of fucoidan, a unique, naturally active sulfate polysaccharide.
Laminarin is known for its outstanding multiple bioactives, but its role in lactation remains …

Intestinal microflora promotes Th2-mediated immunity through NLRP3 in damp and heat environments

Y Luo, X Huang, H Hu, Y Wang, X Feng… - Frontiers in …, 2024 - frontiersin.org
Background With the worsening of the greenhouse effect, the correlation between the damp-
heat environment (DH) and the incidence of various diseases has gained increasing …

Oral creatine-modified selenium-based hyaluronic acid nanogel mediated mitochondrial energy recovery to drive the treatment of inflammatory bowel disease

M Huai, M Pei, J Chen, X Duan, Y Zhu, F Yang… - Journal of …, 2024 - Springer
The damnification of mitochondrion is often considered to be an important culprit of
inflammatory bowel disease (IBD), however, there are fewer reports of mechanisms of …