As the largest class of natural products, terpenes have a variety of roles in mediating
antagonistic and beneficial interactions among organisms. They defend many species of …

Understanding the molecular mechanisms underlying synergistic, potentiative and
antagonistic effects of drug combinations could facilitate the discovery of novel efficacious …

Despite great international efforts, malaria still inflicts an enormous toll on human lives,
especially in Africa. Throughout history, antimalarial medicines have been one of the most …

Ozonide OZ439 is a synthetic peroxide antimalarial drug candidate designed to provide a
single-dose oral cure in humans. OZ439 has successfully completed Phase I clinical trials …

Artemisinins are derived from extracts of sweet wormwood (Artemisia annua) and are well
established for the treatment of malaria, including highly drug-resistant strains. Their efficacy …

The global dissemination of drug-resistant Plasmodium falciparum is spurring intense efforts
to implement artemisinin (ART)–based combination therapies for malaria, including …

Since ancient times, humankind has had to struggle against the persistent onslaught of
pathogenic microorganisms. Nowadays, malaria is still the most important infectious disease …

Artemisinin derivatives are the most recent single drugs approved and introduced for public
antimalarial treatment. Although their recommended use is for treatment of Plasmodium …

Despite intensive research extending back to the 1930s, when the first synthetic antimalarial
drugs made their appearance, the repertoire of clinically licensed formulations remains very …

As long as no effective malaria vaccine is available, chemotherapy belongs to the most
important weapons fighting malaria. One of the most promising new drug developments is …