Prodrugs are molecules with little or no pharmacological activity that are converted to the
active parent drug in vivo by enzymatic or chemical reactions or by a combination of the two …

Methods for site-selective transformations of hydroxyl groups in carbohydrate derivatives are
reviewed. The construction of oligosaccharides of defined connectivity hinges on such …

The ruthenium-catalyzed azide alkyne cycloaddition (RuAAC) affords 1, 5-disubstituted 1, 2,
3-triazoles in one step and complements the more established copper-catalyzed reaction …

Nucleoside, nucleotide, and base analogs have been in the clinic for decades to treat both
viral pathogens and neoplasms. More than 20% of patients on anticancer chemotherapy …

The ProTide technology is a prodrug approach developed for the efficient intracellular
delivery of nucleoside analogue monophosphates and monophosphonates. In this …

Prodrugs are cunning derivatives of therapeutic agents designed to improve the
pharmacokinetics profile of the drug. Within a prodrug, pharmacological activity of the drug is …

The stereoselective synthesis of molecules bearing stereogenic phosphorus (V) centers
represents an enduring challenge in organic chemistry. Although stereospecific nucleophilic …

Since the development of BisP* ligand by Imamoto, P-stereogenic phosphines bearing a
bulky tert-butyl group and a smaller alkyl group have demonstrated extraordinary proficiency …

The catalytic asymmetric synthesis of the anti‐COVID‐19 drug Remdesivir has been
realized by the coupling of the P‐racemic phosphoryl chloride with protected nucleoside …

Abstract The bisphosphonates ((HO) 2 P (O) CR 1 R 2 P (O)(OH) 2, BPs) were first shown to
inhibit bone resorption in the 1960s, but it was not until 30 years later that a detailed …