New promises and challenges in the treatment of advanced non-small-cell lung cancer

ML Meyer, BG Fitzgerald, L Paz-Ares, F Cappuzzo… - The Lancet, 2024 - thelancet.com
Targeted therapies and immunotherapies have radically improved treatment for advanced
non-small-cell lung cancer (NSCLC). Tyrosine kinase inhibitors targeting oncogenic driver …

Recent advances in formulation and application of molecular polymer brushes in biomedicine: Therapeutic, diagnostic, and theranostics capabilities

F Adeli, F Abbasi, P Ghandforoushan, HE Külahlı… - Nano Today, 2023 - Elsevier
The applications of nanotechnology in medical sciences, especially in drug and gene
delivery, has experienced unprecedented growth in recent years. The integration of …

Monoclonal antibodies and antibody-drug conjugates as emerging therapeutics for breast cancer treatment

S Saini, N Gulati, R Awasthi, V Arora… - Current drug …, 2024 - ingentaconnect.com
When breast cells divide and multiply out of control, it is called breast cancer. Symptoms
include lump formation in the breast, a change in the texture or color of the breast, or a …

[HTML][HTML] Recent advances in aptamer-based therapeutic strategies for targeting cancer stem cells

B Liu, J Liu, X Hu, W Xiang, W Hou, C Li, J Wang… - Materials Today Bio, 2023 - Elsevier
Cancer stem cells (CSCs) are believed to be the main cause of chemotherapy resistance
and tumor relapse. Various therapeutic strategies to eliminate CSCs have been developed …

Detailed curriculum vitae of HER2-targeted therapy

XN Zhang, Y Gao, XY Zhang, NJ Guo, WQ Hou… - Pharmacology & …, 2023 - Elsevier
With the booming development of precision medicine, molecular targeted therapy has been
widely used in clinical oncology treatment due to a smaller number of side effects and its …

Therapeutic strategies for non-small cell lung cancer: Experimental models and emerging biomarkers to monitor drug efficacies

C Bourreau, L Treps, S Faure, D Fradin… - Pharmacology & …, 2023 - Elsevier
While new targeted therapies have considerably changed the treatment and prognosis of
non-small cell lung cancer (NSCLC), they are frequently unsuccessful due to primary or …

RIPTACs: a groundbreaking approach to drug discovery

Z Ma, AA Bolinger, J Zhou - Drug discovery today, 2023 - Elsevier
Regulated induced proximity targeting chimeras (RIPTACs), a new class of
heterobifunctional molecules, show promise in specifically targeting and eliminating cancer …

Ginkgo biloba endopleura: An unexplored industrial waste as a potential source of flavonoids, lipids and anti-lung cancer compounds

Y Liu, H Xin, W Li, N Shen, Y Cui - Industrial Crops and Products, 2022 - Elsevier
Ginkgo nuts have been traditionally consumed as food and medicine throughout the world.
However, people usually only use the kernel of ginkgo nuts as food source and the Ginkgo …

[PDF][PDF] Current role of topoisomerase I inhibitors for the treatment of mesenchymal malignancies and their potential future use as payload of sarcoma-specific antibody …

P Schöffski, CC Wang, MP Schöffski… - Oncology Research and …, 2024 - karger.com
Background: Topoisomerase I is an enzyme that plays a crucial part in DNA replication and
transcription by the relaxation of supercoiled double-stranded DNA. Topoisomerase I …

Development of Apoptotic-Cell-Inspired Antibody–Drug Conjugate for Effective Immune Modulation

G Lee, T Iwase, S Matsumoto, A Nabil… - International Journal of …, 2023 - mdpi.com
Background: Apoptotic cells' phosphoserine (PS) groups have a significant
immunosuppressive effect. They inhibit proinflammatory signals by interacting with various …