Monoligated palladium (0) species, L1Pd (0), have emerged as the most active catalytic
species in the cross-coupling cycle. Today, there are methods available to generate the …

Synthetic organic chemistry experienced a significant advance in the last quarter of the 20th
century with the advent of the transition-metal catalyzed cross-coupling reactions. The utility …

Although machine learning bears enormous potential to accelerate developments in
homogeneous catalysis, the frequent need for extensive experimental data can be a …

Cross-coupling reactions, which were discovered almost 50 years ago, are widely used in
both industry and academia. Even though cross-coupling reactions now represent mature …

We review here new developments in decreasing the catalyst loadings in palladium‐
catalyzed C–C bond‐formation reactions to mol ppm or mol ppb levels. This decreases the …

Azine‐containing biaryls are ubiquitous scaffolds in many areas of chemistry, and efficient
methods for their synthesis are continually desired. Pyridine rings are prominent amongst …

Despite the enormous potential for the use of stereospecific cross-coupling reactions to
rationally manipulate the three-dimensional structure of organic molecules, the factors that …

Sonogashira coupling represents an indispensable tool for the preparation of organic
materials that contain C (sp)–C (sp2) bonds. Improving the efficiency and generality of this …

Conspectus The development of homogeneous catalysts is strongly connected to the design
of new, sophisticated ligands, which resolve limitations of a given reaction protocol by …

The Suzuki–Miyaura cross-coupling between polyfluorinated arylboron nucleophiles and
aryl halides enables the efficient construction of polyfluorinated structural motifs frequently …