[HTML][HTML] The human transcription factors
Transcription factors (TFs) recognize specific DNA sequences to control chromatin and
transcription, forming a complex system that guides expression of the genome. Despite keen …
transcription, forming a complex system that guides expression of the genome. Despite keen …
Transcription factor–DNA binding: beyond binding site motifs
S Inukai, KH Kock, ML Bulyk - Current opinion in genetics & development, 2017 - Elsevier
Sequence-specific transcription factors (TFs) regulate gene expression by binding to cis-
regulatory elements in promoter and enhancer DNA. While studies of TF–DNA binding have …
regulatory elements in promoter and enhancer DNA. While studies of TF–DNA binding have …
HOCOMOCO: towards a complete collection of transcription factor binding models for human and mouse via large-scale ChIP-Seq analysis
IV Kulakovskiy, IE Vorontsov, IS Yevshin… - Nucleic acids …, 2018 - academic.oup.com
We present a major update of the HOCOMOCO collection that consists of patterns
describing DNA binding specificities for human and mouse transcription factors. In this …
describing DNA binding specificities for human and mouse transcription factors. In this …
[HTML][HTML] G-quadruplexes are transcription factor binding hubs in human chromatin
Background The binding of transcription factors (TF) to genomic targets is critical in the
regulation of gene expression. Short, double-stranded DNA sequence motifs are routinely …
regulation of gene expression. Short, double-stranded DNA sequence motifs are routinely …
hTFtarget: a comprehensive database for regulations of human transcription factors and their targets
Transcription factors (TFs) as key regulators play crucial roles in biological processes. The
identification of TF–target regulatory relationships is a key step for revealing functions of TFs …
identification of TF–target regulatory relationships is a key step for revealing functions of TFs …
PlantPAN3. 0: a new and updated resource for reconstructing transcriptional regulatory networks from ChIP-seq experiments in plants
CN Chow, TY Lee, YC Hung, GZ Li… - Nucleic acids …, 2019 - academic.oup.com
Abstract The Plant Promoter Analysis Navigator (PlantPAN; http://PlantPAN. itps. ncku. edu.
tw/) is an effective resource for predicting regulatory elements and reconstructing …
tw/) is an effective resource for predicting regulatory elements and reconstructing …
[HTML][HTML] SARS-CoV-2 receptor ACE2 is an interferon-stimulated gene in human airway epithelial cells and is detected in specific cell subsets across tissues
There is pressing urgency to understand the pathogenesis of the severe acute respiratory
syndrome coronavirus clade 2 (SARS-CoV-2), which causes the disease COVID-19. SARS …
syndrome coronavirus clade 2 (SARS-CoV-2), which causes the disease COVID-19. SARS …
[HTML][HTML] Determination and inference of eukaryotic transcription factor sequence specificity
Transcription factor (TF) DNA sequence preferences direct their regulatory activity, but are
currently known for only∼ 1% of eukaryotic TFs. Broadly sampling DNA-binding domain …
currently known for only∼ 1% of eukaryotic TFs. Broadly sampling DNA-binding domain …
miRBase: annotating high confidence microRNAs using deep sequencing data
A Kozomara, S Griffiths-Jones - Nucleic acids research, 2014 - academic.oup.com
We describe an update of the miRBase database (http://www. mirbase. org/), the primary
microRNA sequence repository. The latest miRBase release (v20, June 2013) contains 24 …
microRNA sequence repository. The latest miRBase release (v20, June 2013) contains 24 …
[HTML][HTML] Chemosensitive relapse in small cell lung cancer proceeds through an EZH2-SLFN11 axis
Small cell lung cancer is initially highly responsive to cisplatin and etoposide but in almost
every case becomes rapidly chemoresistant, leading to death within 1 year. We modeled …
every case becomes rapidly chemoresistant, leading to death within 1 year. We modeled …