Tumor necrosis factor-α signaling in macrophages

N Parameswaran, S Patial - Critical Reviews™ in Eukaryotic …, 2010 - dl.begellhouse.com
Tumor necrosis factor-α (TNFα) was cloned over 2 decades ago and its identification in part
led to the discovery of a super family of tumor necrosis factors (TNFs) and their receptors …

NFkappaB is a key player in the crosstalk between inflammation and cardiovascular diseases

A Fiordelisi, G Iaccarino, C Morisco, E Coscioni… - International journal of …, 2019 - mdpi.com
Inflammation is a key mechanism of cardiovascular diseases. It is an essential component of
atherosclerosis and a significant risk factor for the development of cardiovascular events. In …

G protein-coupled receptor kinases: more than just kinases and not only for GPCRs

EV Gurevich, JJG Tesmer, A Mushegian… - Pharmacology & …, 2012 - Elsevier
G protein-coupled receptor (GPCR) kinases (GRKs) are best known for their role in
homologous desensitization of GPCRs. GRKs phosphorylate activated receptors and …

G protein-coupled receptor kinases as therapeutic targets in the heart

J Pfleger, K Gresham, WJ Koch - Nature Reviews Cardiology, 2019 - nature.com
G protein-coupled receptors (GPCRs) are critical cellular sensors that mediate numerous
physiological processes. In the heart, multiple GPCRs are expressed on various cell types …

The evolving impact of g protein-coupled receptor kinases in cardiac health and disease

PY Sato, JK Chuprun, M Schwartz… - Physiological …, 2015 - journals.physiology.org
G protein-coupled receptors (GPCRs) are important regulators of various cellular functions
via activation of intracellular signaling events. Active GPCR signaling is shut down by GPCR …

A selective microRNA-based strategy inhibits restenosis while preserving endothelial function

G Santulli, A Wronska, K Uryu… - The Journal of …, 2014 - Am Soc Clin Investig
Drugs currently approved to coat stents used in percutaneous coronary interventions do not
discriminate between proliferating vascular smooth muscle cells (VSMCs) and endothelial …

Application of micro RNA s in diagnosis and treatment of cardiovascular disease

A Wronska, I Kurkowska‐Jastrzebska… - Acta …, 2015 - Wiley Online Library
Cardiovascular disease (CVD) is a major cause of morbidity and mortality worldwide.
Innovative, more stringent diagnostic and prognostic biomarkers and effective treatment …

Regulation of IκBα Function and NF‐κB Signaling: AEBP1 Is a Novel Proinflammatory Mediator in Macrophages

A Majdalawieh, HS Ro - Mediators of inflammation, 2010 - Wiley Online Library
NF‐κB comprises a family of transcription factors that are critically involved in various
inflammatory processes. In this paper, the role of NF‐κB in inflammation and atherosclerosis …

microRNAs distinctively regulate vascular smooth muscle and endothelial cells: functional implications in angiogenesis, atherosclerosis, and in-stent restenosis

G Santulli - microRNA: Basic Science: From Molecular Biology to …, 2015 - Springer
Endothelial cells (EC) and vascular smooth muscle cells (VSMC) are the main cell types
within the vasculature. We describe here how microRNAs (miRs)—noncoding RNAs that …

Endothelial cells are able to synthesize and release catecholamines both in vitro and in vivo

D Sorriento, G Santulli, C Del Giudice, A Anastasio… - …, 2012 - Am Heart Assoc
Recently it has been demonstrated that catecholamines are produced and used by
macrophages and mediate immune response. The aim of this study is to verify whether …