Brain function critically relies on blood vessels to supply oxygen and nutrients, to establish a
barrier for neurotoxic substances, and to clear waste products. The archetypal vascular …

One compelling challenge in the therapy of epilepsy is to develop anti-epileptogenic drugs
with an impact on the disease progression. The search for novel targets has focused …

The development of the nervous and vascular systems constitutes primary events in the
evolution of the animal kingdom; the former provides electrical stimuli and coordination …

VEGF is a prototype angiogenic factor, but recent evidence indicates that this growth factor
also has direct effects on neural cells. Abnormal regulation of VEGF expression has now …

Previous studies from our group, focusing on neuro-glial remodelling in human temporal
lobe epilepsy (TLE), have shown the presence of immature vascular cells in various areas of …

It is anticipated that by 2040 neurodegeneration will affect 40 million people worldwide,
more than twice as many as today. The traditional neurocentric view holds that …

The blood brain barrier (BBB) plays an important role in the homeostatic regulation of the
brain microenvironment and maintains the immune-privileged status of the brain by …

Recent studies have implicated glial cells in modulation of synaptic transmission, so it is
plausible that glial cells may have a functional role in the hyperexcitability characteristic of …

Interleukin-1β is rapidly synthesized by glia after the induction of seizures. Recent evidence
shows that endogenous IL-1β has proconvulsant actions mediated by interleukin-1 receptor …

Post-traumatic epilepsy (PTE) is one of the most devastating long-term, network
consequences of traumatic brain injury (TBI). There is currently no approved treatment that …