Prebiotic peptides: Molecular hubs in the origin of life
The fundamental roles that peptides and proteins play in today's biology makes it almost
indisputable that peptides were key players in the origin of life. Insofar as it is appropriate to …
indisputable that peptides were key players in the origin of life. Insofar as it is appropriate to …
From self-replication to replicator systems en route to de novo life
P Adamski, M Eleveld, A Sood, Á Kun… - Nature Reviews …, 2020 - nature.com
The process by which chemistry can give rise to biology remains one of the biggest
mysteries in contemporary science. The de novo synthesis and origin of life both require the …
mysteries in contemporary science. The de novo synthesis and origin of life both require the …
Catalytic peptide assemblies
O Zozulia, MA Dolan, IV Korendovych - Chemical Society Reviews, 2018 - pubs.rsc.org
Self-assembly of molecules often results in new emerging properties. Even very short
peptides can self-assemble into structures with a variety of physical and structural …
peptides can self-assemble into structures with a variety of physical and structural …
Thioesters provide a plausible prebiotic path to proto-peptides
It is widely assumed that the condensation of building blocks into oligomers and polymers
was important in the origins of life. High activation energies, unfavorable thermodynamics …
was important in the origins of life. High activation energies, unfavorable thermodynamics …
Amyloid and the origin of life: self-replicating catalytic amyloids as prebiotic informational and protometabolic entities
CPJ Maury - Cellular and Molecular Life Sciences, 2018 - Springer
A crucial stage in the origin of life was the emergence of the first molecular entity that was
able to replicate, transmit information, and evolve on the early Earth. The amyloid world …
able to replicate, transmit information, and evolve on the early Earth. The amyloid world …
A prebiotic template-directed peptide synthesis based on amyloids
The prebiotic replication of information-coding molecules is a central problem concerning
life's origins. Here, we report that amyloids composed of short peptides can direct the …
life's origins. Here, we report that amyloids composed of short peptides can direct the …
Aldolase Cascade Facilitated by Self‐Assembled Nanotubes from Short Peptide Amphiphiles
Early evolution benefited from a complex network of reactions involving multiple C− C bond
forming and breaking events that were critical for primitive metabolism. Nature gradually …
forming and breaking events that were critical for primitive metabolism. Nature gradually …
Spontaneous emergence of self-replicating molecules containing nucleobases and amino acids
The conditions that led to the formation of the first organisms and the ways that life originates
from a lifeless chemical soup are poorly understood. The recent hypothesis of “RNA-peptide …
from a lifeless chemical soup are poorly understood. The recent hypothesis of “RNA-peptide …
Peptide amyloids in the origin of life
J Greenwald, W Kwiatkowski, R Riek - Journal of molecular biology, 2018 - Elsevier
How life can emerge from non-living matter is one of the fundamental mysteries of the
universe. A bottom-up approach to this problem focuses on the potential chemical …
universe. A bottom-up approach to this problem focuses on the potential chemical …
From amino acid mixtures to peptides in liquid sulphur dioxide on early Earth
F Sauer, M Haas, C Sydow, AF Siegle… - Nature …, 2021 - nature.com
The formation of peptide bonds is one of the most important biochemical reaction steps.
Without the development of structurally and catalytically active polymers, there would be no …
Without the development of structurally and catalytically active polymers, there would be no …