Lipoic acid (LA), an endogenous small molecule in organisms, has been extensively used
for the highly efficient clinical treatment of malignant diseases, which include diabetes …

α-Lipoic acid (ALA) is a naturally occurring sulfur-containing fatty acid with high antioxidant
activity. It is also used to treat diabetes, nerve pain, weight loss, heart disease, and primary …

The oxidation of alkenes to vicinal diols using osmium tetroxide is one of the most selective
and reliable transformations in organic synthesis. The reaction stereospecifically produces a …

Introduction: Lipoic acid (LA), a naturally occurring 1, 2-dithiolane analog that plays an
essential role in mitochondrial bioenergetic reactions, has gained unprecedented attention …

Several hundreds of studies published the last decade have reported that α-lipoic acid (LA)
possesses the potential to intervene in various therapeutically interesting pathways …

In this work, we have identified a significantly improved variant (S131Y/Q252I) of the natural
ϵ‐keto ester reductase CpAR2 from Candida parapsilosis for efficiently manufacturing (R)‐8 …

The asymmetric synthesis of both the antipodes of α-lipoic acid is described. The total
synthesis of racemic and asymmetric lipoic acid is achieved from propane 1, 3-diol. This …

Enantioselective synthesis of R-(+)-α and S-(−)-α-lipoic acid - ScienceDirect Skip to main
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The Mukaiyama aldol reaction between the functionalised aldehydes 5 and the S‐ketene
silyl acetal 2 catalysed by 1, 1′‐binaphthyl‐derived chiral titanium (iv) complex 4 afforded …

An efficient, short and convenient asymmetric synthesis of (R)-(+)-lipoic acid in seven steps
from chiral hydroxy aldehyde with 32.5% overall yield is described. Synthesis of S and R …