Loss of skeletal muscle mass occurs frequently in clinical settings in response to joint
immobilization and bed rest, and is induced by a combination of unloading and inactivity …

Skeletal muscle atrophy is defined as a decrease in muscle mass and it occurs when protein
degradation exceeds protein synthesis. Potential triggers of muscle wasting are long-term …

Type I Interferons (IFN-Is) are a family of cytokines which play a major role in inhibiting viral
infection. Resultantly, many viruses have evolved mechanisms in which to evade the IFN-I …

Mitochondrial quality control is essential in highly structured cells such as neurons and
muscles. In skeletal muscle the mitochondrial fission proteins are reduced in different …

Mitochondrial dysfunction occurs during aging, but its impact on tissue senescence is
unknown. Here, we find that sedentary but not active humans display an age-related decline …

Summary N 6-methyladenosine (m 6 A) affects multiple aspects of mRNA metabolism and
regulates developmental transitions by promoting mRNA decay. Little is known about the …

Stresses like low nutrients, systemic inflammation, cancer or infections provoke a catabolic
state characterized by enhanced muscle proteolysis and amino acid release to sustain liver …

Through the generation of humanized FUS mice expressing full-length human FUS, we
identify that when expressed at near endogenous murine FUS levels, both wild-type and …

The circadian timing system synchronizes cellular function by coordinating rhythmic
transcription via a transcription-translational feedback loop. How the circadian system …

Mitochondrial dysfunction and accumulation of damaged mitochondria are considered major
contributors to aging. However, the molecular mechanisms responsible for these …