Endocrine cells within the pancreatic islets of Langerhans are heterogeneous in terms of
transcriptional profile, protein expression and the regulation of hormone release. Even …

Although β-cell heterogeneity was discovered more than 50 years ago, the underlying
principles have been explored only during the past decade. Islet-cell heterogeneity arises …

The pancreatic islets are composed of discrete hormone-producing cells that orchestrate
systemic glucose homeostasis. Here we identify subsets of beta cells using a single-cell …

We hypothesized that the known heterogeneity of pancreatic β cells was due to
subpopulations of β cells at different stages of their life cycle with different functional …

Insulin-secreting β-cells are functionally heterogeneous. Whether there exist cells driving the
first-phase calcium response in individual islets, has not been examined. We examine “first …

Insulin-secreting β-cells are heterogeneous in their regulation of hormone release. While
long known, recent technological advances and new markers have allowed the identification …

The appearance of multicellular organisms imposed the development of several
mechanisms for cell-to-cell communication, whereby different types of cells coordinate their …

The pancreatic beta cell functions as a key regulator of blood glucose levels by integrating a
variety of signals in response to changing metabolic demands. Variations in beta cell identity …

Pancreatic β-cells perform glucose-stimulated insulin secretion, a process at the center of
type 2 diabetes etiology. Efforts to understand how β-cells behave in healthy and stressful …

Pancreatic β-cells play a pivotal role in maintaining normoglycemia. Recent studies have
revealed that the β-cell is not a homogeneous cell population but, rather, is heterogeneous …