[HTML][HTML] Alterations in heparan sulfate proteoglycan synthesis and sulfation and the impact on vascular endothelial function

D Pretorius, RP Richter, T Anand, JC Cardenas… - Matrix Biology Plus, 2022 - Elsevier
The glycocalyx attached to the apical surface of vascular endothelial cells is a rich network
of proteoglycans, glycosaminoglycans, and glycoproteins with instrumental roles in vascular …

Endothelial glycocalyx in hepatopulmonary syndrome: An indispensable player mediating vascular changes

L Li, C Cook, Y Liu, J Li, J Jiang, S Li - Frontiers in Immunology, 2022 - frontiersin.org
Hepatopulmonary syndrome (HPS) is a serious pulmonary vascular complication that
causes respiratory insufficiency in patients with chronic liver diseases. HPS is characterized …

A pharmacoproteomic landscape of organotypic intervention responses in Gram-negative sepsis

T Mohanty, CAQ Karlsson, Y Chao… - Nature …, 2023 - nature.com
Sepsis is the major cause of mortality across intensive care units globally, yet details of
accompanying pathological molecular events remain unclear. This knowledge gap has …

Predictive value of lactate/albumin ratio for death and multiple organ dysfunction syndrome in patients with sepsis

Q Chen, H Zhan, J Chen, J Mo… - Journal of Medical …, 2024 - pmc.ncbi.nlm.nih.gov
Background Multiple organ dysfunction syndrome (MODS) is common after sepsis and
increases mortality. Lactate (Lac) can assess the prognosis of patients. Albumin (Alb) is …

Sepsis-associated endothelial glycocalyx damage: a review of animal models, clinical evidence, and molecular mechanisms

JH Zhan, J Wei, YJ Liu, PX Wang, XY Zhu - International Journal of …, 2025 - Elsevier
In the mammalian cardiovascular system, endothelial glycocalyx is a gel-like layer that
covers the luminal surface of endothelial cells (ECs) and plays crucial roles in vascular …

ADAM10-a “multitasker” in sepsis: Focus on its posttranslational target

S Liao, Y Lin, L Liu, S Yang, YY Lin, J He… - Inflammation Research, 2023 - Springer
Background Sepsis has a complex pathogenesis in which the uncontrolled systemic
inflammatory response triggered by infection leads to vascular barrier disruption …

Therapeutic potential of isoallolithocholic acid in methicillin-resistant Staphylococcus Aureus peritoneal infection

Y Lu, J Du, S Peng, Y Wang, Y Xiao - The Journal of Antibiotics, 2024 - nature.com
A significant increase in multidrug-resistant Methicillin-resistant Staphylococcus aureus
(MRSA) infections has made it crucial to explore new antimicrobial drugs and strategies …

Sepsis-Induced Endothelial Dysfunction: Permeability and Regulated Cell Death

W Zhang, L Jiang, X Tong, H He… - Journal of Inflammation …, 2024 - Taylor & Francis
Sepsis is a life-threatening organ dysfunction caused by a dysregulated host response to
infection. Endothelial cells (ECs) are an important cell type typically affected in sepsis …

[HTML][HTML] Glycosaminoglycans: Participants in microvascular coagulation of sepsis

N Li, R Hao, P Ren, J Wang, J Dong… - Thrombosis and …, 2024 - thieme-connect.com
Sepsis represents a syndromic response to infection and frequently acts as a common
pathway leading to fatality in the context of various infectious diseases globally. The …

[PDF][PDF] Glycosaminoglycans: Participants in Microvascular Coagulation of Sepsis

NLR Hao, P Ren, J Wang, J Dong, T Ye… - Thrombosis and …, 2024 - scienceopen.com
Sepsis represents a syndromic response to infection and frequently acts as a common
pathway leading to fatality in the context of various infectious diseases globally. The …