Integrated virtual screening and MD simulation approaches toward discovering potential inhibitors for targeting BRPF1 bromodomain in hepatocellular carcinoma
Hepatocellular carcinoma (HCC) is one of the most aggressive and life-threatening cancers.
Although multiple treatment options are available, the prognosis of HCC patients is poor due …
Although multiple treatment options are available, the prognosis of HCC patients is poor due …
[HTML][HTML] Novel inhibitors of bromodomain and extra-terminal domain trigger cell death in breast cancer cell lines
M Rahnasto-Rilla, T Puumalainen, V Karttunen… - Bioorganic & Medicinal …, 2024 - Elsevier
Small molecule inhibitors targeting the bromodomain and extra-terminal domain (BET)
family proteins have emerged as a promising class of anti-cancer drugs. Nevertheless, the …
family proteins have emerged as a promising class of anti-cancer drugs. Nevertheless, the …
[HTML][HTML] Identification of PLAC1 as a prognostic biomarker and molecular target in clear cell renal cell carcinoma
Y Kong, Z Jia, Y Sun, L Jin, T Zhang, Q Xu, Y Huang - Cellular Signalling, 2025 - Elsevier
Clear cell renal cell carcinoma (ccRCC) is a common clinical tumor of the urinary system.
The lack of effective diagnostic and treatment options poses a serious challenge to clinical …
The lack of effective diagnostic and treatment options poses a serious challenge to clinical …