Age-associated epigenetic changes in mammalian sperm: implications for offspring health and development

V Ashapkin, A Suvorov, JR Pilsner… - Human reproduction …, 2023 - academic.oup.com
BACKGROUND Modern reproductive behavior in most developed countries is characterized
by delayed parenthood. Older gametes are generally less fertile, accumulating and …

Early developmental conditioning of later health and disease: physiology or pathophysiology?

MA Hanson, PD Gluckman - Physiological reviews, 2014 - journals.physiology.org
Extensive experimental animal studies and epidemiological observations have shown that
environmental influences during early development affect the risk of later pathophysiological …

The environment and male reproduction: The effect of cadmium exposure on reproductive function and its implication in fertility

C De Angelis, M Galdiero, C Pivonello, C Salzano… - Reproductive …, 2017 - Elsevier
Cadmium is an environmental pollutant known as endocrine disruptor. Testis is particularly
susceptible to cadmium, and testis injury occurs at high but even low levels of exposure …

Genetics of male infertility

C Krausz, V Rosta, RS Swerdloff, C Wang - Emery and rimoin's principles …, 2022 - Elsevier
Approximately 7% of men suffer from fertility problems, the etiology of which are ascribable
to a number of factors acting at pretesticular, posttesticular, or testicular levels. About 20% of …

Types, causes, detection and repair of DNA fragmentation in animal and human sperm cells

C González-Marín, J Gosálvez, R Roy - International journal of molecular …, 2012 - mdpi.com
Concentration, motility and morphology are parameters commonly used to determine the
fertilization potential of an ejaculate. These parameters give a general view on the quality of …

Epigenetics in male reproduction: effect of paternal diet on sperm quality and offspring health

U Schagdarsurengin, K Steger - Nature Reviews Urology, 2016 - nature.com
Epigenetic inheritance and its underlying molecular mechanisms are among the most
intriguing areas of current biological and medical research. To date, studies have shown that …

Paternal factors contributing to embryo quality

S Colaco, D Sakkas - Journal of assisted reproduction and genetics, 2018 - Springer
Purpose Advancing maternal and paternal age leads to a decrease in fertility, and hence,
many infertile couples opt for assisted reproductive technologies [ART] to achieve biological …

Epigenetics and male reproduction: the consequences of paternal lifestyle on fertility, embryo development, and children lifetime health

L Stuppia, M Franzago, P Ballerini, V Gatta… - Clinical …, 2015 - Springer
The correlation between epigenetics and human reproduction represents a very interesting
field of study, mainly due to the possible transgenerational effects related to epigenetic …

Genotoxic potential of bisphenol A: A review

I Ďurovcová, S Kyzek, J Fabová, J Makuková… - Environmental …, 2022 - Elsevier
Bisphenol A (BPA), as a major component of some plastic products, is abundant
environmental pollutant. Due to its ability to bind to several types of estrogen receptors, it …

Environmental epigenetics: prospects for studying epigenetic mediation of exposure–response relationships

VK Cortessis, DC Thomas, AJ Levine, CV Breton… - Human genetics, 2012 - Springer
Abstract Changes in epigenetic marks such as DNA methylation and histone acetylation are
associated with a broad range of disease traits, including cancer, asthma, metabolic …