Cerebral plasticity: Windows of opportunity in the developing brain

FY Ismail, A Fatemi, MV Johnston - European journal of paediatric …, 2017 - Elsevier
Background Neuroplasticity refers to the inherently dynamic biological capacity of the central
nervous system (CNS) to undergo maturation, change structurally and functionally in …

Dystonia

B Balint, NE Mencacci, EM Valente, A Pisani… - Nature reviews Disease …, 2018 - nature.com
Dystonia is a neurological condition characterized by abnormal involuntary movements or
postures owing to sustained or intermittent muscle contractions. Dystonia can be the …

Pathogenesis of dystonia: is it of cerebellar or basal ganglia origin?

R Kaji, K Bhatia, AM Graybiel - Journal of Neurology, Neurosurgery & …, 2018 - jnnp.bmj.com
Dystonia is a disorder of motor programmes controlling semiautomatic movements or
postures, with clinical features such as sensory trick, which suggests sensorimotor mismatch …

Striatal cholinergic dysfunction as a unifying theme in the pathophysiology of dystonia

KLE Jaunarajs, P Bonsi, MF Chesselet… - Progress in …, 2015 - Elsevier
Dystonia is a movement disorder of both genetic and non-genetic causes, which typically
results in twisted posturing due to abnormal muscle contraction. Evidence from dystonia …

[HTML][HTML] Dystonia and dopamine: from phenomenology to pathophysiology

B Ribot, J Aupy, M Vidailhet, J Mazere, A Pisani… - Progress in …, 2019 - Elsevier
A line of evidence suggests that the pathophysiology of dystonia involves the striatum,
whose activity is modulated among other neurotransmitters, by the dopaminergic system …

The integrated stress response pathway and neuromodulator signaling in the brain: lessons learned from dystonia

N Calakos, ZF Caffall - The Journal of Clinical Investigation, 2024 - Am Soc Clin Investig
The integrated stress response (ISR) is a highly conserved biochemical pathway involved in
maintaining proteostasis and cell health in the face of diverse stressors. In this Review, we …

[HTML][HTML] Parkinsonism driven by antipsychotics originates from dopaminergic control of striatal cholinergic interneurons

G Kharkwal, K Brami-Cherrier, JE Lizardi-Ortiz… - Neuron, 2016 - cell.com
Typical antipsychotics can cause disabling side effects. Specifically, antagonism of D2R
signaling by the typical antipsychotic haloperidol induces parkinsonism in humans and …

Striatal synaptic dysfunction in dystonia and levodopa-induced dyskinesia

M Scarduzio, EJ Hess, DG Standaert… - Neurobiology of …, 2022 - Elsevier
This review provides an overview of the synaptic dysfunctions of neuronal circuits and
underlying neurochemical alterations observed in the hyperkinetic movement disorders …

Recurrent implication of striatal cholinergic interneurons in a range of neurodevelopmental, neurodegenerative, and neuropsychiatric disorders

LA Poppi, KT Ho-Nguyen, A Shi, CT Daut… - Cells, 2021 - mdpi.com
Cholinergic interneurons are “gatekeepers” for striatal circuitry and play pivotal roles in
attention, goal-directed actions, habit formation, and behavioral flexibility. Accordingly …

Dystonia as a network disorder: a concept in evolution

T Schirinzi, G Sciamanna, NB Mercuri… - Current opinion in …, 2018 - journals.lww.com
Dystonia as a network disorder: a concept in evolution : Current Opinion in Neurology Dystonia
as a network disorder: a concept in evolution : Current Opinion in Neurology Log in or Register …