Dystonia is a neurological condition characterized by abnormal involuntary movements or postures owing to sustained or intermittent muscle contractions. Dystonia can be the …
R Kaji, K Bhatia, AM Graybiel - Journal of Neurology, Neurosurgery & …, 2018 - jnnp.bmj.com
Dystonia is a disorder of motor programmes controlling semiautomatic movements or postures, with clinical features such as sensory trick, which suggests sensorimotor mismatch …
Dystonia is a movement disorder of both genetic and non-genetic causes, which typically results in twisted posturing due to abnormal muscle contraction. Evidence from dystonia …
A line of evidence suggests that the pathophysiology of dystonia involves the striatum, whose activity is modulated among other neurotransmitters, by the dopaminergic system …
N Calakos, ZF Caffall - The Journal of Clinical Investigation, 2024 - Am Soc Clin Investig
The integrated stress response (ISR) is a highly conserved biochemical pathway involved in maintaining proteostasis and cell health in the face of diverse stressors. In this Review, we …
Typical antipsychotics can cause disabling side effects. Specifically, antagonism of D2R signaling by the typical antipsychotic haloperidol induces parkinsonism in humans and …
This review provides an overview of the synaptic dysfunctions of neuronal circuits and underlying neurochemical alterations observed in the hyperkinetic movement disorders …
LA Poppi, KT Ho-Nguyen, A Shi, CT Daut… - Cells, 2021 - mdpi.com
Cholinergic interneurons are “gatekeepers” for striatal circuitry and play pivotal roles in attention, goal-directed actions, habit formation, and behavioral flexibility. Accordingly …
T Schirinzi, G Sciamanna, NB Mercuri… - Current opinion in …, 2018 - journals.lww.com
Dystonia as a network disorder: a concept in evolution : Current Opinion in Neurology Dystonia as a network disorder: a concept in evolution : Current Opinion in Neurology Log in or Register …