This trial sought to evaluate whether vericiguat, a novel oral soluble guanylate cyclase
(sGC) stimulator, was superior to placebo, on a background of standard of care, in …

The prevalence of heart failure (HF) due to cardiac remodelling after acute myocardial
infarction (AMI) does not decrease regardless of implementation of new technologies …

Globally, a staggering 310 million major surgeries are performed each year; around 40 to 50
million in USA and 20 million in Europe. It is estimated that 1–4% of these patients will die …

Aging is associated with an increased risk of cardiovascular disease and death. Here we
show that oral supplementation of the natural polyamine spermidine extends the lifespan of …

Ventricular–arterial coupling (VAC) plays a major role in the physiology of cardiac and aortic
mechanics, as well as in the pathophysiology of cardiac disease. VAC assessment …

Background: Cardiovascular disease in patients with breast cancer is of growing concern.
The longitudinal effects of commonly used therapies, including doxorubicin and …

In the late 19th century, Otto Frank published the first description of a ventricular pressure-
volume diagram, thus laid the foundation for modern cardiovascular physiology. Since then …

Abstract Purpose of Review Given that the life expectancy and the burden of hypertension
are projected to increase over the next decade, hypertensive heart disease (HHD) may be …

Cardiovascular (CV) disease impacts tens of millions of people annually and carries a
massive global economic burden. Continued advances in medical imaging, hardware and …

Background: Arterial hypertension is the most common comorbidity in patients with heart
failure with preserved ejection fraction (HFpEF) and mediates adverse hemodynamics …