Alternative cleavage and polyadenylation in health and disease
Most human genes have multiple sites at which RNA 3ʹ end cleavage and polyadenylation
can occur, enabling the expression of distinct transcript isoforms under different conditions …
can occur, enabling the expression of distinct transcript isoforms under different conditions …
A network-biology perspective of microRNA function and dysfunction in cancer
MicroRNAs (miRNAs) participate in most aspects of cellular differentiation and homeostasis,
and consequently have roles in many pathologies, including cancer. These small non …
and consequently have roles in many pathologies, including cancer. These small non …
mirDIP 4.1—integrative database of human microRNA target predictions
MicroRNAs are important regulators of gene expression, achieved by binding to the gene to
be regulated. Even with modern high-throughput technologies, it is laborious and expensive …
be regulated. Even with modern high-throughput technologies, it is laborious and expensive …
Predicting effective microRNA target sites in mammalian mRNAs
MicroRNA targets are often recognized through pairing between the miRNA seed region
and complementary sites within target mRNAs, but not all of these canonical sites are …
and complementary sites within target mRNAs, but not all of these canonical sites are …
Tools for sequence-based miRNA target prediction: what to choose?
ÁL Riffo-Campos, I Riquelme… - International journal of …, 2016 - mdpi.com
MicroRNAs (miRNAs) are defined as small non-coding RNAs~ 22 nt in length. They regulate
gene expression at a post-transcriptional level through complementary base pairing with the …
gene expression at a post-transcriptional level through complementary base pairing with the …
Therapeutic targeting of microRNAs: current status and future challenges
Z Li, TM Rana - Nature reviews Drug discovery, 2014 - nature.com
MicroRNAs (miRNAs) are evolutionarily conserved small non-coding RNAs that have crucial
roles in regulating gene expression. Increasing evidence supports a role for miRNAs in …
roles in regulating gene expression. Increasing evidence supports a role for miRNAs in …
RNAInter in 2020: RNA interactome repository with increased coverage and annotation
Y Lin, T Liu, T Cui, Z Wang, Y Zhang, P Tan… - Nucleic acids …, 2020 - academic.oup.com
Research on RNA-associated interactions has exploded in recent years, and increasing
numbers of studies are not limited to RNA–RNA and RNA–protein interactions but also …
numbers of studies are not limited to RNA–RNA and RNA–protein interactions but also …
Identification and consequences of miRNA–target interactions—beyond repression of gene expression
Comparative genomics analyses and high-throughput experimental studies indicate that a
microRNA (miRNA) binds to hundreds of sites across the transcriptome. Although the …
microRNA (miRNA) binds to hundreds of sites across the transcriptome. Although the …
The multiMiR R package and database: integration of microRNA–target interactions along with their disease and drug associations
Y Ru, KJ Kechris, B Tabakoff, P Hoffman… - Nucleic acids …, 2014 - academic.oup.com
Abstract microRNAs (miRNAs) regulate expression by promoting degradation or repressing
translation of target transcripts. miRNA target sites have been catalogued in databases …
translation of target transcripts. miRNA target sites have been catalogued in databases …
miRNA–target chimeras reveal miRNA 3′-end pairing as a major determinant of Argonaute target specificity
Abstract microRNAs (miRNAs) act as sequence-specific guides for Argonaute (AGO)
proteins, which mediate posttranscriptional silencing of target messenger RNAs. Despite …
proteins, which mediate posttranscriptional silencing of target messenger RNAs. Despite …