The placenta: a maternofetal interface

K O'Brien, Y Wang - Annual Review of Nutrition, 2023 - annualreviews.org
The placenta is the gatekeeper between the mother and the fetus. Over the first trimester of
pregnancy, the fetus is nourished by uterine gland secretions in a process known as …

Prenatal and postnatal choline supplementation in fetal alcohol spectrum disorder

AM Ernst, BA Gimbel, E de Water, JK Eckerle… - Nutrients, 2022 - mdpi.com
Fetal alcohol spectrum disorder (FASD) is common and represents a significant public
health burden, yet very few interventions have been tested in FASD. Cognitive deficits are …

The prevalence of fetal alcohol spectrum disorders in rural communities in South Africa: A third regional sample of child characteristics and maternal risk factors

PA May, MM de Vries, AS Marais… - Alcoholism: Clinical …, 2022 - Wiley Online Library
Background This study is the ninth cross‐sectional community study of fetal alcohol
spectrum disorders (FASD) conducted by the multidisciplinary Fetal Alcohol Syndrome …

Prenatal alcohol exposure is associated with changes in placental gene co-expression networks

MA Deyssenroth, RP Williams, C Lesseur… - Scientific reports, 2024 - nature.com
Alcohol consumption during pregnancy can result in a range of adverse postnatal outcomes
among exposed children. However, identifying at-risk children is challenging given the …

Fetal alcohol spectrum disorder and iron homeostasis

R Bradley, KL Lakpa, M Burd, S Mehta, MZ Katusic… - Nutrients, 2022 - mdpi.com
Prenatal alcohol exposure results in a spectrum of behavioral, cognitive, and morphological
abnormalities collectively referred to as fetal alcohol spectrum disorder (FASD). FASD …

Alterations in placental inflammation-related gene expression partially mediate the effects of prenatal alcohol consumption on maternal iron homeostasis

JJ Masehi-Lano, M Deyssenroth, SW Jacobson… - Nutrients, 2023 - mdpi.com
Prenatal alcohol exposure (PAE) is associated with alterations in maternal and infant iron
homeostasis that are consistent with changes seen in the setting of inflammation. We …

Fetal anemia and elevated hepcidin in a mouse model of fetal alcohol spectrum disorder

KK Helfrich, N Saini, ST Kwan, OC Rivera… - Pediatric …, 2023 - nature.com
Introduction Prenatal alcohol exposure (PAE) impairs offspring growth and cognition, and
this is worsened by concurrent iron deficiency. Alcohol disrupts fetal iron metabolism and …

[HTML][HTML] Gestational weight gain and dietary energy, iron, and choline intake predict severity of fetal alcohol growth restriction in a prospective birth cohort

RC Carter, M Senekal, CP Duggan, NC Dodge… - The American Journal of …, 2022 - Elsevier
Background Animal models have demonstrated that maternal nutrition can alter fetal
vulnerability to prenatal alcohol exposure (PAE). Few human studies have examined the …

Alcohol exposure suppresses ribosome biogenesis and causes nucleolar stress in cranial neural crest cells

GR Flentke, TE Wilkie, J Baulch, Y Huang, SM Smith - PLoS One, 2024 - journals.plos.org
Prenatal alcohol exposure (PAE) causes cognitive impairment and a distinctive craniofacial
dysmorphology, due in part to apoptotic losses of the pluripotent cranial neural crest cells …

Potential roles of imprinted genes in the teratogenic effects of alcohol on the placenta, somatic growth, and the developing brain

OR Gutherz, M Deyssenroth, Q Li, K Hao… - Experimental …, 2022 - Elsevier
Despite several decades of research and prevention efforts, fetal alcohol spectrum disorders
(FASD) remain the most common preventable cause of neurodevelopmental disabilities …