Acromegaly: pathogenesis, diagnosis, and management

M Fleseriu, F Langlois, DST Lim… - The Lancet Diabetes & …, 2022 - thelancet.com
Growth hormone-secreting pituitary adenomas that cause acromegaly arise as monoclonal
expansions of differentiated somatotroph cells and are usually sporadic. They are almost …

Systemic complications of acromegaly and the impact of the current treatment landscape: an update

MR Gadelha, L Kasuki, DST Lim… - Endocrine reviews, 2019 - academic.oup.com
Acromegaly is a chronic systemic disease with many complications and is associated with
increased mortality when not adequately treated. Substantial advances in acromegaly …

Acromegaly: an endocrine society clinical practice guideline

L Katznelson, ER Laws Jr, S Melmed… - The Journal of …, 2014 - academic.oup.com
Objective: The aim was to formulate clinical practice guidelines for acromegaly. Participants:
The Task Force included a chair selected by the Endocrine Society Clinical Guidelines …

Acromegaly

S Melmed - New England Journal of Medicine, 2006 - Mass Medical Soc
Pituitary tumors account for about 15% of primary intracranial neoplasms. Proliferation of
pituitary cells, which secrete hormones, may result in a spectrum of endocrine symptoms …

A consensus on the diagnosis and treatment of acromegaly complications

S Melmed, FF Casanueva, A Klibanski, MD Bronstein… - Pituitary, 2013 - Springer
Abstract In March 2011, the Acromegaly Consensus Group met to revise and update the
guidelines on the diagnosis and treatment of acromegaly complications. The meeting was …

American Association of Clinical Endocrinologists medical guidelines for clinical practice for the diagnosis and treatment of acromegaly-2011 update

L Katznelson, JLD Atkinson, DM Cook… - Endocrine …, 2011 - endocrinepractice.org
AACE= American Association of Clinical Endocrinologists; BEL=“best evidence” level;
BMD= bone mineral density; CPAP= continuous positive airway pressure; CPG= clinical …

Mortality in acromegaly: a metaanalysis

OM Dekkers, NR Biermasz, AM Pereira… - The Journal of …, 2008 - academic.oup.com
Context: Several studies have assessed mortality risk in patients treated for acromegaly. All
studies found a mortality that was higher than expected for the general population, but most …

Acromegaly

A Colao, LFS Grasso, A Giustina, S Melmed… - Nature Reviews …, 2019 - nature.com
Acromegaly is characterized by increased release of growth hormone and, consequently,
insulin-like growth factor I (IGF1), most often by a pituitary adenoma. Prolonged exposure to …

60 years of neuroendocrinology: acromegaly

C Capatina, JAH Wass - Journal of Endocrinology, 2015 - joe.bioscientifica.com
Acromegaly (ACM) is a chronic, progressive disorder caused by the persistent
hypersecretion of GH, in the vast majority of cases secreted by a pituitary adenoma. The …

Quality of life (QoL) impairments in patients with a pituitary adenoma: a systematic review of QoL studies

CD Andela, M Scharloo, AM Pereira, AA Kaptein… - Pituitary, 2015 - Springer
Purpose Pituitary adenomas give rise to physical and psychological symptoms, which may
persist after biochemical cure. Growing attention has been paid to quality of life (QoL) in …