Ubiquitin signaling is a conserved, widespread, and dynamic process in which protein
substrates are rapidly modified by ubiquitin to impact protein activity, localization, or stability …

Ubiquitylation is a reversible protein modification that is implicated in many cellular
functions. Recently, much progress has been made in the characterization of a superfamily …

Bacteria use a variety of secreted virulence factors to manipulate host cells, thereby causing
significant morbidity and mortality. We report a mechanism for the long-distance delivery of …

From the moment of cotranslational insertion into the lipid bilayer of the endoplasmic
reticulum (ER), newly synthesized integral membrane proteins are subject to a complex …

Abstract The epithelial Na+ channel (ENaC) transports Na+ across tight epithelia, including
the distal nephron. Different paradigms of ENaC regulation include extrinsic and intrinsic …

The members of the organic anion transporter (OAT) family are mainly expressed in kidney,
liver, placenta, intestine, and brain. These transporters play important roles in the disposition …

The epithelial Na+ channel (ENaC) is a major regulator of salt and water reabsorption in a
number of epithelial tissues. Abnormalities in ENaC function have been directly linked to …

Introduction: Cystic fibrosis is an autosomal recessive disorder caused by mutations in the
cystic fibrosis transmembrane conductance regulator (CFTR) gene that codes for the CFTR …

The aldosterone-sensitive distal nephron (ASDN) includes the late distal convoluted tubule
2, the connecting tubule (CNT) and the collecting duct. The appropriate regulation of sodium …

Major histocompatibility complex (MHC) molecules are key players in initiating immune
responses towards invading pathogens. Both MHC class I and class II genes are present in …