Mammals have two specialized vascular circulatory systems: the blood vasculature and the
lymphatic vasculature. The lymphatic vasculature is a unidirectional conduit that returns …

Primary congenital glaucoma (PCG) is a severe disease characterized by developmental
defects in the trabecular meshwork (TM) and Schlemm's canal (SC), comprising the …

More than 76 million people worldwide are afflicted with the neurodegenerative eye
diseases described and grouped together as glaucoma. A common feature amongst the …

Introduction Primary open angle glaucoma (POAG) is a leading cause of blindness globally.
Characterized by progressive retinal ganglion cell degeneration, the precise pathogenesis …

This review article focuses on the pathogenesis of and genetic defects linked with chronic
ocular hypertension (cOHT) and glaucoma. The latter ocular disease constitutes a group of …

Background: Schlemm's canal (SC) is a large vessel residing in the iridocorneal angle and
is required to regulate aqueous humor outflow. Normal SC structure and function is …

Ocular toxicity studies are the bedrock of nonclinical ocular drug and drug–device
development, and there has been an evolution in experience, technologies, and challenges …

Purpose: The angiopoietin-1 (ANG1)-TIE signaling pathway orchestrates the development
and maintenance of the Schlemm's canal (SC). In this study, we investigated the impact of …

Purpose Genome-wide association studies have recently uncovered many loci associated
with variation in intraocular pressure (IOP). Artificial intelligence (AI) can be used to …

Pathogenesis of many eye diseases can be traced to certain genetic defects at the cell
nuclear level and/or due to deficiency or dysfunctions in the gene product proteins …