Perineuronal nets (PNNs) are extracellular matrix (ECM) chondroitin sulfate proteoglycan
(CSPG)-containing structures that surround the soma and dendrites of various mammalian …

The widespread adoption of microfluidic devices among the neuroscience and neurobiology
communities has enabled addressing a broad range of questions at the molecular, cellular …

Microglia, the resident immune cells of the brain, have emerged as crucial regulators of
synaptic refinement and brain wiring. However, whether the remodeling of distinct synapse …

The brain is the central and most complex organ in the nervous system, comprising billions
of neurons that constantly communicate through trillions of connections called synapses …

A key feature of excitatory synapses is the existence of subsynaptic protein nanoclusters
(NCs) whose precise alignment across the cleft in a transsynaptic nanocolumn influences …

The mechanistic underpinnings of autism remain a subject of debate and controversy. Why
do individuals with autism share an overlapping set of atypical behaviors and symptoms …

The activity-dependent rules that govern the wiring of GABAergic interneurons are not well
understood. Chandelier cells (ChCs) are a type of GABAergic interneuron that control …

Disrupted synaptic inhibition is implicated in neuropsychiatric disorders, yet the molecular
mechanisms that shape and sustain inhibitory synapses are poorly understood. Here, we …

Astrocytes strongly promote the formation and maturation of synapses by secreted proteins.
Several astrocyte-secreted synaptogenic proteins controlling excitatory synapse …

The diversification of cell adhesion molecules by alternative splicing is proposed to underlie
molecular codes for neuronal wiring. Transcriptomic approaches mapped detailed cell-type …