Breast cancer is a heterogeneous disease encompassing a variety of entities with distinct
morphological features and clinical behaviors. Although morphology is often associated with …

The epithelium of the mammary gland exists in a highly dynamic state, undergoing dramatic
morphogenetic changes during puberty, pregnancy, lactation, and regression. The recent …

Background: Previously, small studies have found that BRCA1 and BRCA2 breast tumors
differ in their pathology. Analysis of larger datasets of mutation carriers should allow further …

Breast cancers in BRCA1 mutation carriers frequently have a distinctive basal-like
phenotype. It has been suggested that this results from an origin in basal breast epithelial …

Sporadic basal-like cancers (BLC) are a distinct class of human breast cancers that are
phenotypically similar to BRCA1-associated cancers. Like BRCA1-deficient tumors, most …

Although many genes that lead to different types of cancer when mutated have been
identified, the cells that initiate tumour formation following accumulation of these mutations …

E-cadherin and P-cadherin are major contributors to cell–cell adhesion in epithelial tissues,
playing pivotal roles in important morphogenetic and differentiation processes during …

Breast cancer is a highly prevalent disease, accounting for 29% of invasive cancers in
women. Survival from this disease depends on the stage at diagnosis, with patients who are …

Breast cancers arising in germline carriers of BRCA1 mutations have a characteristic
phenotype that has been shown in many studies to differentiate BRCA1 tumours from …

Background Hereditary breast cancer runs in families where several members in different
generations are affected. Most of these breast cancers are caused by mutations in the high …