Long-term normothermic machine preservation of human livers: what is needed to succeed?
Although short‐term machine perfusion (≤ 24 h) allows for resuscitation and viability
assessment of high‐risk donor livers, the donor organ shortage might be further remedied by …
assessment of high‐risk donor livers, the donor organ shortage might be further remedied by …
Screening for mitochondrial function before use-routine liver assessment during hypothermic oxygenated perfusion impacts liver utilization
J Eden, E Breuer, D Birrer, M Müller, M Pfister… - …, 2023 - thelancet.com
Background To report on a concept of liver assessment during ex situ hypothermic
oxygenated perfusion (HOPE) and its significant impact on liver utilization. Methods An …
oxygenated perfusion (HOPE) and its significant impact on liver utilization. Methods An …
Identification of myeloid-derived growth factor as a mechanically-induced, growth-promoting angiocrine signal for human hepatocytes
L Große-Segerath, P Follert, K Behnke, J Ettich… - Nature …, 2024 - nature.com
Recently, we have shown that after partial hepatectomy (PHx), an increased hepatic blood
flow initiates liver growth in mice by vasodilation and mechanically-triggered release of …
flow initiates liver growth in mice by vasodilation and mechanically-triggered release of …
Observations and findings during the development of a subnormothermic/normothermic long‐term ex vivo liver perfusion machine
Background Ex situliver machine perfusion at subnormothermic/normothermic temperature
isincreasingly applied in the field of transplantation to store and evaluateorgans on the …
isincreasingly applied in the field of transplantation to store and evaluateorgans on the …
Production of physiological amounts of hemostatic proteins by human donor livers during ex situ long-term normothermic machine perfusion for up to 7 days
B Lascaris, SB Bodewes, J Adelmeijer… - Journal of Thrombosis …, 2024 - Elsevier
Background Normothermic machine perfusion (NMP) is used for preservation and
assessment of human donor livers prior to transplantation. During NMP, the liver is …
assessment of human donor livers prior to transplantation. During NMP, the liver is …
Effect of cardiopulmonary bypass on coagulation factors II, VII and X in a primate model: an exploratory pilot study
T Shimoda, C Liu, BJ Mathis, Y Goto… - … and thoracic surgery, 2023 - academic.oup.com
OBJECTIVES The use of cardiopulmonary bypass (CPB) in cardiac surgery is a major risk
factor for postoperative bleeding. We hypothesized that consumptive coagulopathy and …
factor for postoperative bleeding. We hypothesized that consumptive coagulopathy and …
Preservation of coagulation function by normothermic machine perfusion in liver transplant as evidenced by thromboelastography parameters
LL Su, DT Secor, AK McGary, MC Nguyen… - Liver …, 2024 - journals.lww.com
The use of normothermic machine perfusion over static cold storage in liver transplantation
has been shown to reduce post-transplant risks of early allograft dysfunction, primary …
has been shown to reduce post-transplant risks of early allograft dysfunction, primary …
Normothermic machine-perfused human donor livers produce functional hemostatic proteins
SB Bodewes, B Lascaris, J Adelmeijer… - …, 2023 - journals.lww.com
Background. Normothermic machine perfusion (NMP) is used for the viability assessment of
high-risk donor livers before transplantation. The production of hemostatic proteins is one of …
high-risk donor livers before transplantation. The production of hemostatic proteins is one of …
Pigs or Pumps: A new strategy emerges for liver perfusion
JI Kim, A Torres-Hernandez, A Griesemer - Hepatology, 2023 - journals.lww.com
In 2022, over 9000 liver transplants were performed. However, more than 10,000 individuals
remain on the liver transplant list—over half of whom have been on the waiting list for longer …
remain on the liver transplant list—over half of whom have been on the waiting list for longer …