There is increasing appreciation that non-neuronal cells contribute to the initiation,
progression and pathology of diverse neurodegenerative disorders. This Review focuses on …

The understanding of lysosomes has come a long way since the initial discovery of their role
in degrading cellular waste. The lysosome is now recognized as a highly dynamic organelle …

Microglia are crucial for maintaining brain health and neuron function. Here, we report that
microglia establish connections with neurons using tunneling nanotubes (TNTs) in both …

The biological basis of the neurodegenerative movement disorder, Parkinson's disease
(PD), is still unclear despite it being 'discovered'over 200 years ago in Western Medicine …

Background Astrocytes play a central role in maintaining brain energy metabolism, but are
also tightly connected to the pathogenesis of Alzheimer's disease (AD). Our previous studies …

Accumulation of advanced glycation end products (AGEs) on biopolymers accompanies
cellular aging and drives poorly understood disease processes. Here, we studied how AGEs …

Abstract Alpha-synuclein (α-syn) has been suggested to have many functions including,
vesicle transport in neurons, transcriptional regulator, modulator of immune cell maturation …

Parkinson's disease (PD) is an age-related neurodegenerative disorder, diagnosed on the
basis of typical motor disturbances, but also characterized by the presence of non-motor …

Parkinson's disease (PD) is a growing cause of disability worldwide and there is a critical
need for the development of disease-modifying therapies to slow or stop disease …

Parkinson's disease (PD) is a common neurodegenerative disorder that primarily affects the
elderly. While the etiology of PD is likely multifactorial with the involvement of genetic …