Neisseria gonorrhoeae vaccines: a contemporary overview

E Williams, KL Seib, CK Fairley… - Clinical Microbiology …, 2024 - Am Soc Microbiol
Neisseria gonorrhoeae infection is an important public health issue, with an annual global
incidence of 87 million. N. gonorrhoeae infection causes significant morbidity and can have …

Looking beyond meningococcal B with the 4CMenB vaccine: the Neisseria effect

Y Ruiz García, WY Sohn, KL Seib, MK Taha… - npj Vaccines, 2021 - nature.com
Infections with Neisseria meningitidis and Neisseria gonorrhoeae have different clinical
manifestations, but the bacteria share up to 80–90% genome sequence identity. The …

Effectiveness of a group B outer membrane vesicle meningococcal vaccine against gonorrhoea in New Zealand: a retrospective case-control study

H Petousis-Harris, J Paynter, J Morgan, P Saxton… - The Lancet, 2017 - thelancet.com
Background Gonorrhoea is a major global public health problem that is exacerbated by drug
resistance. Effective vaccine development has been unsuccessful, but surveillance data …

Effectiveness and impact of the 4CMenB vaccine against invasive serogroup B meningococcal disease and gonorrhoea in an infant, child, and adolescent programme …

B Wang, L Giles, P Andraweera, M McMillan… - The Lancet Infectious …, 2022 - thelancet.com
Background A programme of vaccination with the four-component serogroup B
meningococcal (4CMenB) vaccine was introduced in South Australia for infants and children …

The Serogroup B Meningococcal Vaccine Bexsero Elicits Antibodies to Neisseria gonorrhoeae

EA Semchenko, A Tan, R Borrow… - Clinical Infectious …, 2019 - academic.oup.com
Abstract Background Neisseria gonorrhoeae and Neisseria meningitidis are closely-related
bacteria that cause a significant global burden of disease. Control of gonorrhoea is …

[HTML][HTML] Gonococcal vaccines: public health value and preferred product characteristics; report of a WHO global stakeholder consultation, January 2019

SL Gottlieb, F Ndowa, EW Hook III, C Deal… - Vaccine, 2020 - Elsevier
Renewed interest in developing vaccines against Neisseria gonorrhoeae has been sparked
by the increasing threat of gonococcal antimicrobial resistance (AMR) and growing optimism …

Effectiveness of a group B outer membrane vesicle meningococcal vaccine in preventing hospitalization from gonorrhea in New Zealand: a retrospective cohort study

J Paynter, F Goodyear-Smith, J Morgan, P Saxton… - Vaccines, 2019 - mdpi.com
Gonorrhea is a major global public health problem with emergence of multiple drug-resistant
strains with no effective vaccine. This retrospective cohort study aimed to estimate the …

Microencapsulated IL-12 drives genital tract immune responses to intranasal gonococcal outer membrane vesicle vaccine and induces resistance to vaginal infection …

Y Liu, LA Hammer, J Daamen, M Stork, NK Egilmez… - Msphere, 2023 - Am Soc Microbiol
An experimental gonococcal vaccine consisting of outer membrane vesicles (OMVs) and
microsphere (ms)-encapsulated interleukin-12 (IL-12 ms) induces Th1-driven immunity, with …

Vaccine candidates for the control and prevention of the sexually transmitted disease gonorrhea

EC Haese, VC Thai, CM Kahler - Vaccines, 2021 - mdpi.com
The World Health Organization (WHO) has placed N. gonorrhoeae on the global priority list
of antimicrobial resistant pathogens and is urgently seeking the development of new …

Estimating the population level impact of a gonococcal vaccine candidate: predictions from a simple mathematical model

KA Carey, LM Newman, IH Spicknall - Vaccine, 2022 - Elsevier
Background Neisseria gonorrhoeae cross-protection was suggested in a New Zealand
meningitis B vaccine. We modeled the potential impact of similar vaccines on gonorrhea …