The aim of this review was to discuss an overview of type 2 diabetes; biology of PTP1B; role
of PTP1B in metabolic disorders; and recent updates in the development of PTP1B inhibitors …

This article provides an overview of approximately 300 secondary metabolites with inhibitory
activity against protein tyrosine phosphatase 1B (PTP1B), which were isolated from various …

Berberine was investigated as an inhibitor of human dipeptidyl peptidase IV (DPP IV) in an
attempt to explain its anti-hyperglycemic activities. The investigation included simulated …

Introduction: Protein tyrosine phosphatase 1B (PTP1B) plays an important role in the
negative regulation of insulin signal transduction pathway and has emerged as novel …

Diabetes mellitus is a metabolic disorder of multiple etiologies, characterized by chronic
hyperglycemia together with the disturbance of carbohydrate, fat, protein metabolism …

Diabetes mellitus is a systemic disease responsible for morbidity in the western world and is
gradually becoming prevalent in developing countries too. The prevalence of diabetes is …

Type 2 diabetes patients show defects in insulin signal transduction that include lack of
insulin receptor, decrease in insulin stimulated receptor tyrosine kinase activity and receptor …

Insulin resistance (IR) and the associated hyperinsulinemia are early pathophysiological
changes which, if not well treated, can lead to type 2 diabetes, endothelial dysfunction and …

Diabetes mellitus, which includes both type 1 and type 2 diabetes mellitus (T2DM), is a
major disease that threatens human health worldwide. Protein tyrosine phosphatase 1B …

Commiphora gileadensis L. is an important endangered medicinal plant that belongs to the
family Burseraceae. In this study, C. gileadensis callus culture was established successfully …