A key aspect for successful drug delivery via lipid‐based nanoparticles is their
internalization in target cells. Two prominent examples of such drug delivery systems are …

Membrane rafts are dynamic, small (10–200 nm) domains enriched with cholesterol and
sphingolipids that compartmentalize cellular processes. Rafts participate in roles essential to …

Amyloid peptide (Aβ) is generated by sequential cleavage of the amyloid precursor protein
(APP) by β‐secretase (Bacel) and γ‐secretase. Aβ production increases after plasma …

Clostridium difficile toxin A (TcdA) and toxin B (TcdB), C. sordellii lethal toxin (TcsL) and C.
novyi α-toxin (TcnA) are important pathogenicity factors, which represent the family of the …

Prion protein (PrPc) was originally viewed solely as being involved in prion disease, but now
several intriguing lines of evidence have emerged indicating that it plays a fundamental role …

Lipid rafts, solid regions of the plasma membrane enriched in cholesterol and
glycosphingolipids, are essential parts of a cell. Functionally, lipid rafts present a platform …

Misfolded and abnormal β-sheets forms of wild-type proteins, such as cellular prion protein
(PrPC) and amyloid beta (Aβ), are believed to be the vectors of neurodegenerative …

The hepatitis E virus (HEV) causes large outbreaks and sporadic cases of acute viral
hepatitis in developing countries. In the developed world, HEV occurrence has increased as …

Cellular prion protein (PrP C) is a mammalian glycoprotein which is usually found anchored
to the plasma membrane via a glycosylphosphatidylinositol (GPI) anchor. The precise …

Endocytosis is the fundamental uptake process through which cells internalize extracellular
materials and species. Neurodegenerative diseases (NDs) are characterized by a …