The remarkable T cell receptor (TCR) performs essential functions in the initiation of
intracellular signals required for T cell development, repertoire selection and effector …

Self-reactivity was once seen as a potential characteristic of T cells that was eliminated by
clonal selection to protect the host from autoimmune pathology. It is now understood that the …

High-efficiency nonviral CRISPR/Cas9-mediated gene editing of human T cells using plasmid
donor DNA | Journal of Experimental Medicine | Rockefeller University Press Skip to Main …

T cells react to foreign or self-antigens through T cell receptor (TCR) signaling. Several
decades of research have delineated the mechanism of TCR signal transduction and its …

Thymocyte selection involves the positive and negative selection of the repertoire of T cell
receptors (TCRs) such that the organism does not suffer autoimmunity, yet has the benefit of …

Constitutive activation of the MALT1 paracaspase in conventional T cells of Malt1 TBM/TBM
(TRAF6 Binding Mutant= TBM) mice causes fatal inflammation and autoimmunity, but the …

The ability of T cells to respond to a wide array of foreign antigens while avoiding reactivity
to self is largely determined by cellular selection of developing T cells in the thymus. While a …

T cells carry out the formidable task of identifying small numbers of foreign antigenic
peptides rapidly and specifically against a very noisy environmental background of …

How cells respond to myriad stimuli with finite signaling machinery is central to immunology.
In naive T cells, the inherent effect of ligand strength on activation pathways and endpoints …

An immunocompetent and self-tolerant pool of naive T cells is formed in the thymus through
the process of repertoire selection. T cells that are potentially capable of responding to …