The role of potential oxidative biomarkers in the prognosis of acute ischemic stroke and the exploration of antioxidants as possible preventive and treatment options

FZ Kamal, R Lefter, H Jaber, IM Balmus… - International Journal of …, 2023 - mdpi.com
Ischemic strokes occur when the blood supply to a part of the brain is interrupted or reduced
due to arterial blockage, and it often leads to damage to brain cells or death. According to a …

Signaling pathways in brain ischemia: Mechanisms and therapeutic implications

W Lin, XY Zhao, J Cheng, L Li, Q Jiang… - Pharmacology & …, 2023 - Elsevier
Ischemic stroke occurs when the arteries supplying blood to the brain are narrowed or
blocked, inducing damage to brain tissue due to a lack of blood supply. One effective way to …

Iron homeostasis imbalance and ferroptosis in brain diseases

H Long, W Zhu, L Wei, J Zhao - MedComm, 2023 - Wiley Online Library
Brain iron homeostasis is maintained through the normal function of blood–brain barrier and
iron regulation at the systemic and cellular levels, which is fundamental to normal brain …

CZK, a novel alkaloid derivative from Clausena lansium, alleviates ischemic stroke injury through Nrf2-mediated antioxidant effects

H Chen, Y Liu, J Feng, H Wang, Y Yang, Q Ai… - Scientific Reports, 2023 - nature.com
Anti-oxidant stress is a potential strategy for the treatment of ischemic stroke. Here, we found
a novel free radical scavenger termed as CZK, which is derived from alkaloids contained in …

Effects of medicinal plants and phytochemicals in Nrf2 pathways during inflammatory bowel diseases and related colorectal cancer: A comprehensive review

LF Laurindo, MC de Maio, G Minniti, N de Góes Corrêa… - Metabolites, 2023 - mdpi.com
Inflammatory bowel diseases (IBDs) are related to nuclear factor erythroid 2-related factor 2
(Nrf2) dysregulation. In vitro and in vivo studies using phytocompounds as modulators of the …

Targeting the redox system for cardiovascular regeneration in aging

MS Allemann, P Lee, JH Beer, SS Saeedi Saravi - Aging Cell, 2023 - Wiley Online Library
Cardiovascular aging presents a formidable challenge, as the aging process can lead to
reduced cardiac function and heightened susceptibility to cardiovascular diseases …

Novel insight into the therapeutical potential of flavonoids from traditional Chinese medicine against cerebral ischemia/reperfusion injury

J Zhou, F Sun, W Zhang, Z Feng, Y Yang… - Frontiers in …, 2024 - frontiersin.org
Cerebral ischemia/reperfusion injury (CIRI) is a major contributor to poor prognosis of
ischemic stroke. Flavonoids are a broad family of plant polyphenols which are abundant in …

Anethole pretreatment modulates cerebral Ischemia/Reperfusion: the role of JNK, p38, MMP-2 and MMP-9 pathways

NS Younis, ME Mohamed - Pharmaceuticals, 2023 - mdpi.com
Anethole (AN) is one of the major constituents of several plant oils, demonstrating plentiful
pharmacological actions. Ischemic stroke is the main cause of morbidity and death …

Research progress of prodrugs for the treatment of cerebral ischemia

H Zheng, H Wu, D Wang, S Wang, D Ji, X Liu… - European Journal of …, 2024 - Elsevier
It is well-known that pharmacotherapy plays a pivotal role in the treatment and prevention of
cerebral ischemia. Nevertheless, existing drugs, including numerous natural products …

Sirtuins: promising therapeutic targets to treat ischemic stroke

Y Liu, L Wang, G Yang, X Chi, X Liang, Y Zhang - Biomolecules, 2023 - mdpi.com
Stroke is a major cause of mortality and disability globally, with ischemic stroke (IS)
accounting for over 80% of all stroke cases. The pathological process of IS involves …