[HTML][HTML] Coronavirus biology and replication: implications for SARS-CoV-2
P V'kovski, A Kratzel, S Steiner, H Stalder… - Nature Reviews …, 2021 - nature.com
The SARS-CoV-2 pandemic and its unprecedented global societal and economic disruptive
impact has marked the third zoonotic introduction of a highly pathogenic coronavirus into the …
impact has marked the third zoonotic introduction of a highly pathogenic coronavirus into the …
[HTML][HTML] Role of favipiravir in the treatment of COVID-19
S Joshi, J Parkar, A Ansari, A Vora, D Talwar… - International Journal of …, 2021 - Elsevier
Abstract The coronavirus disease-2019 (COVID-19) outbreak all over the world has led the
researchers to strive to develop drugs or vaccines to prevent or halt the progression of this …
researchers to strive to develop drugs or vaccines to prevent or halt the progression of this …
Favipiravir: A new and emerging antiviral option in COVID-19
U Agrawal, R Raju, ZF Udwadia - Medical Journal Armed Forces India, 2020 - Elsevier
With over 16 million cases reported from across the globe, the SARS-CoV-2, a mere 125
microns in diameter, has left an indelible impact on our world. With the paucity of new drugs …
microns in diameter, has left an indelible impact on our world. With the paucity of new drugs …
[HTML][HTML] Coronavirus RNA proofreading: molecular basis and therapeutic targeting
F Robson, KS Khan, TK Le, C Paris, S Demirbag… - Molecular cell, 2020 - cell.com
Summary The coronavirus disease 2019 (COVID-19) that is wreaking havoc on worldwide
public health and economies has heightened awareness about the lack of effective antiviral …
public health and economies has heightened awareness about the lack of effective antiviral …
Favipiravir at high doses has potent antiviral activity in SARS-CoV-2− infected hamsters, whereas hydroxychloroquine lacks activity
SJF Kaptein, S Jacobs, L Langendries… - Proceedings of the …, 2020 - National Acad Sciences
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) rapidly spread around the
globe after its emergence in Wuhan in December 2019. With no specific therapeutic and …
globe after its emergence in Wuhan in December 2019. With no specific therapeutic and …
COVID‐19: immunopathology, pathophysiological mechanisms, and treatment options
LE van Eijk, M Binkhorst, AR Bourgonje… - The Journal of …, 2021 - Wiley Online Library
Abstract Coronavirus disease 2019 (COVID‐19), caused by severe acute respiratory
syndrome coronavirus 2 (SARS‐CoV‐2), continues to spread globally despite the worldwide …
syndrome coronavirus 2 (SARS‐CoV‐2), continues to spread globally despite the worldwide …
A Comparative Analysis of SARS-CoV-2 Antivirals Characterizes 3CLpro Inhibitor PF-00835231 as a Potential New Treatment for COVID-19
M de Vries, AS Mohamed, RA Prescott… - Journal of …, 2021 - Am Soc Microbiol
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is the etiological agent of
coronavirus disease 2019 (COVID-19). There is a dire need for novel effective antivirals to …
coronavirus disease 2019 (COVID-19). There is a dire need for novel effective antivirals to …
[HTML][HTML] Remdesivir is a delayed translocation inhibitor of SARS-CoV-2 replication
Remdesivir is a nucleoside analog approved by the US FDA for treatment of COVID-19.
Here, we present a 3.9-Å-resolution cryo-EM reconstruction of a remdesivir-stalled RNA …
Here, we present a 3.9-Å-resolution cryo-EM reconstruction of a remdesivir-stalled RNA …
[HTML][HTML] Molecular docking reveals ivermectin and remdesivir as potential repurposed drugs against SARS-CoV-2
AF Eweas, AA Alhossary… - Frontiers in Microbiology, 2021 - frontiersin.org
SARS-CoV-2 is a newly emerged coronavirus that causes a respiratory disease with
variable severity and fatal consequences. It was first reported in Wuhan and subsequently …
variable severity and fatal consequences. It was first reported in Wuhan and subsequently …
Variants in ACE2; potential influences on virus infection and COVID-19 severity
The third pandemic of coronavirus infection, called COVID-19 disease, was first detected in
November 2019th. Various determinants of disease progression such as age, sex, virus …
November 2019th. Various determinants of disease progression such as age, sex, virus …