Advances in nanomedicines for diagnosis of central nervous system disorders
In spite of a great improvement in medical health services and an increase in lifespan, we
have witnessed a skyrocket increase in the incidence of central nervous system (CNS) …
have witnessed a skyrocket increase in the incidence of central nervous system (CNS) …
Cu and Zn interactions with Aβ peptides: consequence of coordination on aggregation and formation of neurotoxic soluble Aβ oligomers
The coordination chemistry of transition metal ions (Fe, Cu, Zn) with the amyloid-β (Aβ)
peptides has attracted a lot of attention in recent years due to its repercussions in …
peptides has attracted a lot of attention in recent years due to its repercussions in …
Anticancer potency of copper (II) complexes of thiosemicarbazones
NK Singh, AA Kumbhar, YR Pokharel… - Journal of Inorganic …, 2020 - Elsevier
Being a structural and catalytic cofactor in a number of biological pathways, copper
accumulates in tumors owing to selective permeability of the cancer cell membranes …
accumulates in tumors owing to selective permeability of the cancer cell membranes …
Amphiphilic distyrylbenzene derivatives as potential therapeutic and imaging agents for soluble and insoluble amyloid β aggregates in Alzheimer's disease
Alzheimer's Disease (AD) is the most common neurodegenerative disease, and efficient
therapeutic and early diagnostic agents for AD are still lacking. Herein, we report the …
therapeutic and early diagnostic agents for AD are still lacking. Herein, we report the …
Copper Coordination Chemistry of Sulfur Pendant Cyclen Derivatives: An Attempt to Hinder the Reductive-Induced Demetalation in 64/67Cu Radiopharmaceuticals
The Cu2+ complexes formed by a series of cyclen derivatives bearing sulfur pendant arms,
1, 4, 7, 10-tetrakis [2-(methylsulfanyl) ethyl]-1, 4, 7, 10-tetraazacyclododecane (DO4S), 1, 4 …
1, 4, 7, 10-tetrakis [2-(methylsulfanyl) ethyl]-1, 4, 7, 10-tetraazacyclododecane (DO4S), 1, 4 …
Metal-chelating benzothiazole multifunctional compounds for the modulation and 64 Cu PET imaging of Aβ aggregation
While Alzheimer's Disease (AD) is the most common neurodegenerative disease, there is
still a dearth of efficient therapeutic and diagnostic agents for this disorder. Reported herein …
still a dearth of efficient therapeutic and diagnostic agents for this disorder. Reported herein …
Antioxidant and copper-chelating power of new molecules suggested as multiple target agents against Alzheimer's disease. A theoretical comparative study
In this study, the scavenging activity against OOH radicals and the copper-chelating ability of
two new synthesized molecules (named L1 and L2) that can act as multiple target agents …
two new synthesized molecules (named L1 and L2) that can act as multiple target agents …
Advances in macrocyclic chelators for positron emission tomography imaging
M Li, S Wang, Q Kong, X Cheng, H Yan, Y Xing, X Lan… - View, 2023 - Wiley Online Library
In recent years, radiometals have been successfully applied to medicine because of their
breadth of decay properties and increased production and availability. Bifunctional chelators …
breadth of decay properties and increased production and availability. Bifunctional chelators …
Potential diagnostic imaging of Alzheimer's disease with copper-64 complexes that bind to amyloid-β plaques
LE McInnes, A Noor, K Kysenius, C Cullinane… - Inorganic …, 2019 - ACS Publications
Amyloid-β plaques, consisting of aggregated amyloid-β peptides, are one of the pathological
hallmarks of Alzheimer's disease. Copper complexes formed using positron-emitting copper …
hallmarks of Alzheimer's disease. Copper complexes formed using positron-emitting copper …
Design of a multivalent bifunctional chelator for diagnostic 64Cu PET imaging in Alzheimer's disease
Herein, we report a 64Cu positron emission tomography (PET) imaging agent that shows
appreciable in vivo brain uptake and exhibits high specific affinity for beta-amyloid (Aβ) …
appreciable in vivo brain uptake and exhibits high specific affinity for beta-amyloid (Aβ) …