Seaweed-derived phlorotannins: a review of multiple biological roles and action mechanisms

F Khan, GJ Jeong, MSA Khan, N Tabassum, YM Kim - Marine Drugs, 2022 - mdpi.com
Phlorotannins are a group of phenolic secondary metabolites isolated from a variety of
brown algal species belonging to the Fucaceae, Sargassaceae, and Alariaceae families …

Structural Diversity of Complex Phloroglucinol Derivatives from Eucalyptus Species

S Faezeh Taghizadeh, A Panahi… - Chemistry & …, 2022 - Wiley Online Library
Several species of the genus Eucalyptus are used in many traditional medicine systems for
the treatment of respiratory tract infections, colds, flu, sore throats, and bronchitis. The genus …

A machine learning model trained on a high-throughput antibacterial screen increases the hit rate of drug discovery

ASMZ Rahman, C Liu, H Sturm… - PLOS Computational …, 2022 - journals.plos.org
Screening for novel antibacterial compounds in small molecule libraries has a low success
rate. We applied machine learning (ML)-based virtual screening for antibacterial activity and …

PTP1B inhibition studies of biological active phloroglucinols from the rhizomes of Dryopteris crassirhizoma: Kinetic properties and molecular docking simulation

NV Phong, VT Oanh, SY Yang, JS Choi, BS Min… - International Journal of …, 2021 - Elsevier
By various chromatographic methods, 30 phloroglucinols (1− 30) were isolated from a
methanol extract of Dryopteris crassirhizoma, including two new dimeric phloroglucinols (13 …

In vitro antibiofilm activity of resveratrol against avian pathogenic Escherichia coli

X Ruan, X Deng, M Tan, C Yu, M Zhang, Y Sun… - BMC Veterinary …, 2021 - Springer
Abstract Background Avian pathogenic Escherichia coli (APEC) strains cause infectious
diseases in poultry. Resveratrol is extracted from Polygonum cuspidatum, Cassia tora Linn …

2, 4-Diacetylphloroglucinol (DAPG) derivatives rapidly eradicate methicillin-resistant staphylococcus aureus without resistance development by disrupting membrane

Y Zhong, X He, W Tao, J Feng, R Zhang, H Gong… - European Journal of …, 2023 - Elsevier
Methicillin-resistant Staphylococcus aureus (MRSA) causes severe public health challenges
throughout the world, and the multi-drug resistance (MDR) of MRSA to antibiotics …

Phloroglucinol derivative carbomer hydrogel accelerates MRSA-infected wounds' healing

X Huang, J Yang, R Zhang, L Ye, M Li… - International Journal of …, 2022 - mdpi.com
Globally, wound infection is considered to be one of the major healthcare problems, with
bacterial infections being the most critical threat, leading to poor and delayed wound …

Integration of synthetic and natural derivatives revives the therapeutic potential of temozolomide against glioma-an in vitro and in vivo perspective

SD Precilla, SS Kuduvalli, EA Praveena, S Thangavel… - Life Sciences, 2022 - Elsevier
Aims Malignant gliomas constitute one of the deadly brain tumors with high degeneration
rate. Though temozolomide (TMZ) is the first-line drug for glioma, its efficacy has decreased …

A greatly improved procedure for the synthesis of an antibiotic-drug candidate 2, 4-diacetylphloroglucinol over silica sulphuric acid catalyst: multivariate optimisation …

T Kusumaningsih, WE Prasetyo, M Firdaus - RSC advances, 2020 - pubs.rsc.org
Efforts toward the development of a straightforward greener Gram-scale synthesis of the
antibiotic compound 2, 4-diacetylphloroglucinol (DAPG) have been developed. This …

Cofactor Engineering Redirects Secondary Metabolism and Enhances Erythromycin Production in Saccharopolyspora erythraea

X Li, J Chen, JM Andersen, J Chu… - ACS Synthetic …, 2020 - ACS Publications
Saccharopolyspora erythraea is used for industrial erythromycin production. To explore the
physiological role of intracellular energy state in metabolic regulation by S. erythraea, we …