A review of progress in single particle tracking: from methods to biophysical insights

C Manzo, MF Garcia-Parajo - Reports on progress in physics, 2015 - iopscience.iop.org
Optical microscopy has for centuries been a key tool to study living cells with minimum
invasiveness. The advent of single molecule techniques over the past two decades has …

Stochastic models of intracellular transport

PC Bressloff, JM Newby - Reviews of Modern Physics, 2013 - APS
The interior of a living cell is a crowded, heterogenuous, fluctuating environment. Hence, a
major challenge in modeling intracellular transport is to analyze stochastic processes within …

Objective comparison of methods to decode anomalous diffusion

G Muñoz-Gil, G Volpe, MA Garcia-March… - Nature …, 2021 - nature.com
Deviations from Brownian motion leading to anomalous diffusion are found in transport
dynamics from quantum physics to life sciences. The characterization of anomalous diffusion …

mTORC1 controls phase separation and the biophysical properties of the cytoplasm by tuning crowding

M Delarue, GP Brittingham, S Pfeffer, IV Surovtsev… - Cell, 2018 - cell.com
Macromolecular crowding has a profound impact on reaction rates and the physical
properties of the cell interior, but the mechanisms that regulate crowding are poorly …

Anomalous diffusion models and their properties: non-stationarity, non-ergodicity, and ageing at the centenary of single particle tracking

R Metzler, JH Jeon, AG Cherstvy… - Physical Chemistry …, 2014 - pubs.rsc.org
Modern microscopic techniques following the stochastic motion of labelled tracer particles
have uncovered significant deviations from the laws of Brownian motion in a variety of …

Bayesian deep learning for error estimation in the analysis of anomalous diffusion

H Seckler, R Metzler - Nature Communications, 2022 - nature.com
Modern single-particle-tracking techniques produce extensive time-series of diffusive motion
in a wide variety of systems, from single-molecule motion in living-cells to movement …

Protein crowding in lipid bilayers gives rise to non-Gaussian anomalous lateral diffusion of phospholipids and proteins

JH Jeon, M Javanainen, H Martinez-Seara, R Metzler… - Physical Review X, 2016 - APS
Biomembranes are exceptionally crowded with proteins with typical protein-to-lipid ratios
being around 1∶ 50− 1∶ 100. Protein crowding has a decisive role in lateral membrane …

When Brownian diffusion is not Gaussian

B Wang, J Kuo, SC Bae, S Granick - Nature materials, 2012 - nature.com
When Brownian diffusion is not Gaussian | Nature Materials Skip to main content Thank you for
visiting nature.com. You are using a browser version with limited support for CSS. To obtain the …

Strange kinetics of single molecules in living cells

E Barkai, Y Garini, R Metzler - Physics today, 2012 - pubs.aip.org
For centuries, physical imaging tools have been opening new frontiers in biology. The
discovery of the cell nucleus by Scottish botanist Robert Brown was made possible by early …

[图书][B] Stochastic processes in cell biology

PC Bressloff - 2014 - Springer
One of the major challenges in modern biology is to understand how the molecular
components of a living cell operate in a highly noisy environment. What are the specific …