Estrogens are known to be important in the growth of breast cancers in both pre and
postmenopausal women. As the number of breast cancer patients increases with age, the …

Many enzymes catalyse reactions that have an oestrogen as a substrate and/or a product.
The reactions catalysed include aromatisation, oxidation, reduction, sulfonation …

Human cytochrome P450 aromatase catalyzes with high specificity the synthesis of
estrogens from androgens. Aromatase inhibitors (AIs) such as exemestane, 6 …

Cytochrome P450 enzymes catalyze a broad diversity of reactions, including well-
established transformations such as carbon and nitrogen hydroxylation, heteroatom …

Aromatase inhibition is considered a legitimate approach for the treatment of ER-positive
(ER+) breast cancer as it accounts for more than 70% of breast cancer cases. Aromatase …

Aromatase inhibitors (AIs) are one of the principal therapeutic approaches for estrogen
receptor-positive (ER+) breast cancer in postmenopausal women. They block estrogen …

Aromatase and estrogen receptor α (ER) are two key proteins for the proliferation of
endocrine-responsive and–resistant breast cancers. Aromatase is an enzyme involved in …

Abstract Cytochrome P450 (P450, CYP) 19A1 is the steroid aromatase, the enzyme
responsible for the 3‐step conversion of androgens (androstenedione or testosterone) to …

Background: Estrogens are essential for the growth of breast cancer in the case of
premenopausal as well as in postmenopausal women. However, most of the breast cancer …

The protein database has> 450 entries with P450 in the title and of these there are
approximately 54 unique structures. Although this sample of unique structures is small …