Metallaphotoredox: the merger of photoredox and transition metal catalysis

AY Chan, IB Perry, NB Bissonnette, BF Buksh… - Chemical …, 2021 - ACS Publications
The merger of photoredox catalysis with transition metal catalysis, termed
metallaphotoredox catalysis, has become a mainstay in synthetic methodology over the past …

Photoredox-catalyzed C–H functionalization reactions

N Holmberg-Douglas, DA Nicewicz - Chemical reviews, 2021 - ACS Publications
The fields of C–H functionalization and photoredox catalysis have garnered enormous
interest and utility in the past several decades. Many different scientific disciplines have …

Radical C(sp3)–H functionalization and cross-coupling reactions

DL Golden, SE Suh, SS Stahl - Nature Reviews Chemistry, 2022 - nature.com
C–H functionalization reactions are playing an increasing role in the preparation and
modification of complex organic molecules, including pharmaceuticals, agrochemicals and …

Accelerating reaction generality and mechanistic insight through additive mapping

CN Prieto Kullmer, JA Kautzky, SW Krska, T Nowak… - Science, 2022 - science.org
Reaction generality is crucial in determining the overall impact and usefulness of synthetic
methods. Typical generalization protocols require a priori mechanistic understanding and …

Metallaphotoredox catalysis for sp 3 C–H functionalizations through hydrogen atom transfer (HAT)

J Zhang, M Rueping - Chemical Society Reviews, 2023 - pubs.rsc.org
In recent years, the integration of photocatalytic hydrogen atom transfer (HAT) with transition
metal catalysis has emerged as a formidable strategy for the construction of C (sp3)–carbon …

Strategies and Mechanisms of First-Row Transition Metal-Regulated Radical C–H Functionalization

X Wang, J He, YN Wang, Z Zhao, K Jiang… - Chemical …, 2024 - ACS Publications
Radical C–H functionalization represents a useful means of streamlining synthetic routes by
avoiding substrate preactivation and allowing access to target molecules in fewer steps. The …

Highly selective synthesis of all-carbon tetrasubstituted alkenes by deoxygenative alkenylation of carboxylic acids

Y Li, Q Shao, H He, C Zhu, XS Xue, J Xie - Nature Communications, 2022 - nature.com
The synthesis of all-carbon tetrasubstituted olefins under mild reaction conditions is
challenging because of the inevitable issues including significant steric hindrance and the …

Upgrading ketone synthesis direct from carboxylic acids and organohalides

R Ruzi, K Liu, C Zhu, J Xie - Nature Communications, 2020 - nature.com
The ketone functional group has a unique reactivity in organic chemistry and is associated
with a number of useful reactions. Catalytic methods for ketone synthesis are continually …

Dual Catalytic Platform for Enabling sp3 α C–H Arylation and Alkylation of Benzamides

AW Rand, H Yin, L Xu, J Giacoboni… - Acs …, 2020 - ACS Publications
A dual catalytic sp3 α C–H arylation and alkylation of benzamides with organic halides is
described. This protocol exhibits an exquisite site selectivity, chemoselectivity, and …

Aldehydes as powerful initiators for photochemical transformations

MA Theodoropoulou, NF Nikitas… - Beilstein Journal of …, 2020 - beilstein-journals.org
Photochemistry, the use of light to promote organic transformations, has been known for
more than a century but only recently has revolutionized the way modern chemists are …