Surgical resection of solid tumors is currently the gold standard and preferred therapeutic
strategy for cancer. Chemotherapy drugs also make a significant contribution by inhibiting …

The high incidence rates of prostate cancer (PCa) raise demand for improved therapeutic
strategies. Prostate tumors specifically express the prostate‐specific membrane antigen …

Herein we describe the design and synthesis of a folate–doxorubicin conjugate with
activatable fluorescence and activatable cytotoxicity. In this study we discovered that the …

The present disclosure generally relates to nanoparticles hav ing about 0.2 to about 35
weight percent of a therapeutic agent; and about 10 to about 99 weight percent of biocom …

Prostate cancer (PCa) is a major cause of mortality and morbidity in Western society today.
Current methods for detecting PCa are limited, leaving most early malignancies …

The targeted delivery of potent cytotoxic agents has emerged as a promising strategy for the
treatment of cancer and other serious conditions. Traditionally, antibodies against markers of …

Prostate specific membrane antigen (PSMA) is a membrane-bound glutamate
carboxypeptidase overexpressed in many forms of prostate cancer. Our laboratory has …

US8613951B2 - Therapeutic polymeric nanoparticles with mTor inhibitors and methods of
making and using same - Google Patents US8613951B2 - Therapeutic polymeric nanoparticles …

US PATENT DOCUMENTS 5,543,158 A 8, 1996 Grefet al. 5,578,325 A 11/1996 Domb et al.
6,007,845. A 12/1999 Domb et al. 6,139,870 A 10, 2000 Verrecchia 6,254,890 B1 7/2001 …

Glutamate carboxypeptidase II (GCPII) in the central nervous system is referred to as the
prostate-specific membrane antigen (PSMA) in the periphery. PSMA serves as a target for …