Importance Parkinson disease is the most common form of parkinsonism, a group of
neurological disorders with Parkinson disease–like movement problems such as rigidity …

Levodopa is the most effective medication for the treatment of the motor symptoms of
Parkinson's disease. However, over time, the clinical response to levodopa becomes …

The natural pattern of progression of Parkinson's disease is largely unknown because
patients are conventionally followed on treatment. As Parkinson's disease progresses, the …

Abstract Machine learning algorithms that use data streams captured from soft wearable
sensors have the potential to automatically detect PD symptoms and inform clinicians about …

Summary Background Many patients with Parkinson's disease have potentially disabling off
episodes that are not predictably responsive to levodopa. In this study, we assessed the …

Abstract Lower Urinary Tract Symptoms (LUTS) are frequently present in the general
population as patients age with approximately a third of individuals experiencing LUTS …

Neurologists nowadays no longer view neurodegenerative diseases, like Parkinson's and
Alzheimer's disease, as single entities, but rather as a spectrum of multifaceted symptoms …

Parkinson's disease (PD) is a neurodegenerative pathology, the origin of which is
associated with the death of neuronal cells involved in the production of dopamine. The …

Parkinson's disease (PD) is characterized by degeneration of dopaminergic neurons in the
substantia nigra pars compacta and other neuronal populations. The worldwide prevalence …

Administration of levodopa for Parkinson's disease (PD) has remained the most effective
therapy for symptom management despite being in use for over 50 years. Advancing …