Harnessing the immune system in glioblastoma

NF Brown, TJ Carter, D Ottaviani… - British journal of cancer, 2018 - nature.com
Glioblastoma is the most common primary malignant brain tumour. Survival is poor and
improved treatment options are urgently needed. Although immunotherapies have emerged …

Challenges in glioblastoma immunotherapy: mechanisms of resistance and therapeutic approaches to overcome them

KJ Habashy, R Mansour, C Moussalem… - British journal of …, 2022 - nature.com
Glioblastoma is the most common and aggressive primary malignant brain tumour. The
prognosis of patients with glioblastoma is poor, and their overall survival averages at 1 year …

Glioblastoma treatments: an account of recent industrial developments

E Alphandéry - Frontiers in pharmacology, 2018 - frontiersin.org
The different drugs and medical devices, which are commercialized or under industrial
development for glioblastoma treatment, are reviewed. Their different modes of action are …

Turning “cold” into “hot” tumors—opportunities and challenges for radio-immunotherapy against primary and metastatic brain cancers

L Sevenich - Frontiers in oncology, 2019 - frontiersin.org
The development of immunotherapies has revolutionized intervention strategies for a variety
of primary cancers. Despite this promising progress, treatment options for primary brain …

Multifunctional lipidic nanocarriers for effective therapy of glioblastoma: recent advances in stimuli-responsive, receptor and subcellular targeted approaches

MM Hegde, S Prabhu, S Mutalik, A Chatterjee… - Journal of …, 2022 - Springer
Background Glioblastoma, or glioblastoma multiforme (GBM), remains a fatal cancer type
despite the remarkable progress in understanding the genesis and propagation of the tumor …

Role of nanomedicine-based therapeutics in the treatment of CNS disorders

ZH Guo, S Khattak, MA Rauf, MA Ansari, MN Alomary… - Molecules, 2023 - mdpi.com
Central nervous system disorders, especially neurodegenerative diseases, are a public
health priority and demand a strong scientific response. Various therapy procedures have …

[HTML][HTML] NAMPT overexpression induces cancer stemness and defines a novel tumor signature for glioma prognosis

A Lucena-Cacace, D Otero-Albiol… - Oncotarget, 2017 - ncbi.nlm.nih.gov
Gliomas are the most prevalent primary malignant brain tumors associated with poor
prognosis. NAMPT, a rate-limiting enzyme that boosts the nicotinamide adenine …

Chimeric antigen receptor T cells in glioblastoma—Current concepts and promising future

R Kringel, K Lamszus, M Mohme - Cells, 2023 - mdpi.com
Glioblastoma (GBM) is a highly aggressive primary brain tumor that is largely refractory to
treatment and, therefore, invariably relapses. GBM patients have a median overall survival of …

An update of nanoparticle-based approaches for glioblastoma multiforme immunotherapy

L Taiarol, B Formicola, RD Magro, S Sesana, F Re - Nanomedicine, 2020 - Taylor & Francis
Glioblastoma multiforme is a serious medical issue in the brain oncology field due to its
aggressiveness and recurrence. Immunotherapy has emerged as a valid approach to …

Epigenetic therapy potentiates transposable element transcription to create tumor-enriched antigens in glioblastoma cells

HJ Jang, NM Shah, JH Maeng, Y Liang, NL Basri… - Nature Genetics, 2024 - nature.com
Inhibiting epigenetic modulators can transcriptionally reactivate transposable elements
(TEs). These TE transcripts often generate unique peptides that can serve as immunogenic …