Strategies for improving the safety and RNAi efficacy of noncovalent peptide/siRNA nanocomplexes

J Wang, G Chen, N Liu, X Han, F Zhao, L Zhang… - Advances in Colloid and …, 2022 - Elsevier
In the past decades, the striking development of cationic polypeptides and cell-penetrating
peptides (CPPs) tailored for small interfering RNA (siRNA) delivery has been fuelled by the …

Histidine‐enhanced gene delivery systems: The state of the art

SE Hooshmand, M Jahanpeimay Sabet… - The Journal of Gene …, 2022 - Wiley Online Library
Gene therapy has emerged as a promising tool for treating different intractable diseases,
particularly cancer or even viral diseases such as COVID‐19 (coronavirus disease 2019). In …

Serum-Resistant Ternary DNA Polyplexes for Suicide Gene Therapy of Uterine Leiomyoma

A Egorova, S Shtykalova, M Maretina, S Freund… - International Journal of …, 2023 - mdpi.com
Uterine leiomyoma (UL) is a prevalent benign tumor in women that frequently gives rise to a
multitude of reproductive complications. The use of suicide gene therapy has been …

Polycondensed peptide carriers modified with cyclic RGD ligand for targeted suicide gene delivery to uterine fibroid cells

A Egorova, S Shtykalova, M Maretina, A Selutin… - International Journal of …, 2022 - mdpi.com
Suicide gene therapy was suggested as a possible strategy for the treatment of uterine
fibroids (UFs), which are the most common benign tumors inwomen of reproductive age. For …

Self-assembling branched amphiphilic peptides for targeted delivery of small molecule anticancer drugs

J Chen, W Wang, Y Wang, X Yuan, C He, P Pei… - European Journal of …, 2022 - Elsevier
Water insolubility poses a significant challenge in the clinical applications of many small
molecule drugs. To improve the drug delivery efficiency, two branched amphiphilic peptides …

Peptide-Based Nanoparticles for αvβ3 Integrin-Targeted DNA Delivery to Cancer and Uterine Leiomyoma Cells

A Egorova, A Selutin, M Maretina, S Selkov, A Kiselev - Molecules, 2022 - mdpi.com
Uterine leiomyoma is the most common benign tumor of the reproductive system. Current
therapeutic options do not simultaneously meet the requirements of long-term efficiency and …

iRGD-Targeted Peptide Nanoparticles for Anti-Angiogenic RNAi-Based Therapy of Endometriosis

A Egorova, M Petrosyan, M Maretina, E Bazian… - Pharmaceutics, 2023 - mdpi.com
Anti-angiogenic RNAi-based therapy can be considered as a possible strategy for the
treatment of endometriosis (EM), which is the most common gynecological disease …

The TSH/thyroid hormones axis and breast cancer

IA Voutsadakis - Journal of Clinical Medicine, 2022 - mdpi.com
Breast cancer, the most prevalent female carcinoma, is characterized by the expression of
steroid nuclear receptors in a subset of cases. The most important nuclear receptor with …

Amphiphilic pH-sensitive polypeptides for siRNA delivery

O Osipova, N Zakharova, I Pyankov, A Egorova… - Journal of Drug Delivery …, 2022 - Elsevier
The effective delivery of nucleic acid therapeutics into tumor cells is of great importance in
terms of cancer gene therapy. Successful application of siRNAs is restricted by the …

Development of irgd-modified peptide carriers for suicide gene therapy of uterine leiomyoma

A Egorova, S Shtykalova, A Selutin, N Shved… - Pharmaceutics, 2021 - mdpi.com
Uterine leiomyoma (UL) is one of the most common benign tumors in women that often
leads to many reproductive complications. Suicide genetherapy was suggested as a …